Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000058.xml
Planta Med 2012; 78(15): 1698-1701
DOI: 10.1055/s-0032-1315255
DOI: 10.1055/s-0032-1315255
Natural Product Chemistry
Letters
Incomptines C and D, Two Heliangolides from Decachaeta incompta and Their Antiprotozoal Activity
Further Information
Publication History
received 16 February 2012
revised 22 June 2012
accepted 23 July 2012
Publication Date:
04 September 2012 (online)
Abstract
Two new heliangolides, incomptines C (3) and D (4), were isolated from the leaves of Decachaeta incompta. The structures were established by spectroscopic methods and confirmed by X-ray crystallography. The antiprotozoal activity of incomptines C and D was evaluated. Additionally, the chromatographic profile of the leaves and roots extracts were compared to identify incomptines A–D (1–4) in each extract.
Key words
Asteraceae - Decachaeta incompta - Giardia lamblia - Entamoeba histolytica - heliangolides - antiprotozoal activity-
References
- 1 Misky M, De Luengo DH, Mabry TJ. Guaiane sequiterpenes from Decachaeta scabrella . Phytochemistry 1987; 26: 199-200
- 2 Misky M, Gage DA, Mabry T. Quercetagetin 6,7,4′-trimethyl ether and 3-sulphate from Decachaeta haenkeana . Phytochemistry 1985; 24: 3078-3080
- 3 De Luengo DH, Misky M, Gage DA, Mabry T. 7α-hydroxy-sesquiterpene lactones from Decachaeta ovatifolia . Phytochemistry 1986; 25: 1917-1922
- 4 Alvarado S, Ciccio JF, Calzada J. Thieleanine, a new guaianolide from Decachaeta thieleana . Phytochemistry 1979; 18: 330
- 5 De Luengo DH, Mabry T. 6-Methoxyflavonoids from Decachaeta ovatifolia . J Nat Prod 1986; 49: 183-184
- 6 Ghantous A, Gali-Muhtasib H, Vourela H, Saliba NA, Darwiche N. What made sesquiterpene lactones reach cancer clinical trials?. Drug Discov Today 2010; 15: 668-678
- 7 Kaur K, Jain M, Kaur T, Jain R. Antimalarials from nature. Bioorg Med Chem 2009; 17: 3229-3256
- 8 Guerrero C, Taboada J, Díaz JB, Oliva A, Ortega A. Incomptinas A y B. Dos heliangólidas aisladas de Decachaeta incompta. Estudio preliminar de las actividades biológicas de incomptina B. Rev Latinoam Quím 1994; 23: 142-147
- 9 Calzada F, Yepez-Mulia L, Tapia-Contreras A, Ortega A. Antiprotozoal and antibacterial properties of Decachaeta incompta . Rev Latinoam Quím 2009; 37: 97-103
- 10 Ya-Ching S, Yiun-Yang J, Ashraf K, Lien C. New germacranolides from Eupatorium hualienense . Chem Biodivers 2005; 2: 244-252