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Semin Liver Dis 2012; 32(02): 130-137
DOI: 10.1055/s-0032-1316468
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Acute Hepatitis C in Patients with HIV

Christoph Boesecke
1   Department of Internal Medicine I, University of Bonn, Bonn, Germany
,
Jürgen Kurt Rockstroh
1   Department of Internal Medicine I, University of Bonn, Bonn, Germany
› Author Affiliations
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Publication History

Publication Date:
03 July 2012 (online)

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Abstract

Almost 10 years ago clinicians started to note the first cases of an outbreak of acute hepatitis C (AHC) infections among human immunodeficiency virus- (HIV-) positive men who have sex with men (MSM) in Europe, soon followed by similar reports from the United States and Australia. In the absence of randomized controlled treatment trials in AHC, coinfection expert consensus recommendations based upon published data from uncontrolled clinical and cohort studies give guidance on best clinical management. Pegylated interferon in combination with weight-adapted ribavirin is still recommended as the treatment of choice for all HCV genotypes. For patients developing a rapid virologic response, treatment duration of 24 weeks is recommended. If antiviral therapy was initiated within 24 weeks after diagnosis, high sustained virologic response rates of 60 to 80% have been observed. Prevention and screening efforts along with early anti-HCV therapy have to be intensified to allow for control of viral dissemination as the current epidemic of AHC particularly among MSM is still ongoing.

Keywords

acute hepatitis C virus - human immunodeficiency virus - HIV - treatment - interferon - ribavirin
 

  • References

  • 1 Luetkemeyer A, Hare CB, Stansell J , et al. Clinical presentation and course of acute hepatitis C infection in HIV-infected patients. J Acquir Immune Defic Syndr 2006; 41 (1) 31-36
    CrossrefPubMedGoogle Scholar
  • 2 Cox AL, Page K, Bruneau J , et al. Rare birds in North America: acute hepatitis C cohorts. Gastroenterology 2009; 136 (1) 26-31
    CrossrefPubMedGoogle Scholar
  • 3 Giraudon I, Ruf M, Maguire H , et al. Increase in diagnosed newly acquired hepatitis C in HIV-positive men who have sex with men across London and Brighton, 2002-2006: is this an outbreak?. Sex Transm Infect 2008; 84 (2) 111-115
    CrossrefPubMedGoogle Scholar
  • 4 Ruf M, Cohuet S, Maguire H , et al; SNAHC Steering Group. Setting up an enhanced surveillance of newly acquired hepatitis C infection in men who have sex with men: a pilot in London and South East region of England. Euro Surveill 2008; 13 (47)
    PubMedGoogle Scholar
  • 5 Vogel M, Deterding K, Wiegand J , et al; German Hepatitis Group; Hep-Net. Initial presentation of acute hepatitis C virus (HCV) infection among HIV-negative and HIV-positive individuals-experience from 2 large German networks on the study of acute HCV infection. Clin Infect Dis 2009; 49 (2) 317-319 , author reply 319
    PubMedGoogle Scholar
  • 6 Gambotti L, Batisse D, Colin-de-Verdiere N , et al; Acute hepatitis C collaborating group. Acute hepatitis C infection in HIV positive men who have sex with men in Paris, France, 2001–2004. Euro Surveill 2005; 10 (5) 115-117
    PubMedGoogle Scholar
  • 7 Morin T, Pariente A, Lahmek P ; Investigator Group of ANGH, SPILF, FNPRH. Favorable outcome of acute occupational hepatitis C in healthcare workers: a multicenter French study on 23 cases. Eur J Gastroenterol Hepatol 2011; 23 (6) 515-520
    PubMedGoogle Scholar
  • 8 Urbanus AT, van de Laar TJ, Stolte IG , et al. Hepatitis C virus infections among HIV-infected men who have sex with men: an expanding epidemic. AIDS 2009; 23 (12) F1-F7
    CrossrefPubMedGoogle Scholar
  • 9 Rauch A, Rickenbach M, Weber R , et al; Swiss HIV Cohort Study. Unsafe sex and increased incidence of hepatitis C virus infection among HIV-infected men who have sex with men: the Swiss HIV Cohort Study. Clin Infect Dis 2005; 41 (3) 395-402
    CrossrefPubMedGoogle Scholar
  • 10 Gallotta G, Gali L, De Bona A , et al. Acute hepatitis C virus in HIV co-infected men who have sex with men: Milan, 1996–2007. Paper presented at: 4th International HIV and Hepatitis Co-infection; June 19–21, 2008; Madrid, Spain.
    Google Scholar
  • 11 Matthews GV, Hellard M, Haber P , et al; Australian Trial in Acute Hepatitis C Study Group. Characteristics and treatment outcomes among HIV-infected individuals in the Australian Trial in Acute Hepatitis C. Clin Infect Dis 2009; 48 (5) 650-658
    CrossrefPubMedGoogle Scholar
  • 12 Sherman KE, Rouster SD, Horn PS. Comparison of methodologies for quantification of hepatitis C virus (HCV) RNA in patients coinfected with HCV and human immunodeficiency virus. Clin Infect Dis 2002; 35 (4) 482-487
    CrossrefPubMedGoogle Scholar
  • 13 Backus LI, Phillips BR, Boothroyd DB , et al. Effects of hepatitis C virus coinfection on survival in veterans with HIV treated with highly active antiretroviral therapy. J Acquir Immune Defic Syndr 2005; 39 (5) 613-619
    PubMedGoogle Scholar
  • 14 United Nations. Report UNAIDS. 2008. Available at: http://data.unaids.org/pub/GlobalReport/2008/jc1511_gr08_executivesummary_en.pdf . Accessed October 18, 2011
    PubMedGoogle Scholar
  • 15 Soriano V, Mocroft A, Rockstroh J , et al; EuroSIDA Study Group. Spontaneous viral clearance, viral load, and genotype distribution of hepatitis C virus (HCV) in HIV-infected patients with anti-HCV antibodies in Europe. J Infect Dis 2008; 198 (9) 1337-1344
    CrossrefPubMedGoogle Scholar
  • 16 Matthews GV, Pham ST, Hellard M , et al; ATAHC Study Group. Patterns and characteristics of hepatitis C transmission clusters among HIV-positive and HIV-negative individuals in the Australian trial in acute hepatitis C. Clin Infect Dis 2011; 52 (6) 803-811
    CrossrefPubMedGoogle Scholar
  • 17 Arends JE, Lambers FA, van der Meer JT , et al; The Netherlands Society for AIDS Physicians-NVAB. Treatment of acute hepatitis C virus infection in HIV+ patients: Dutch recommendations for management. Neth J Med 2011; 69 (1) 43-49
    PubMedGoogle Scholar
  • 18 Neukam K, Nattermann J, Rallón N , et al. Different distributions of hepatitis C virus genotypes among HIV-infected patients with acute and chronic hepatitis C according to interleukin-28B genotype. HIV Med 2011; 12 (8) 487-493
    CrossrefPubMedGoogle Scholar
  • 19 Pfafferott K, Gaudieri S, Ulsenheimer A , et al. Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity. PLoS ONE 2011; 6 (2) e16797
    CrossrefPubMedGoogle Scholar
  • 20 Bottieau E, Apers L, Van Esbroeck M, Vandenbruaene M, Florence E. Hepatitis C virus infection in HIV-infected men who have sex with men: sustained rising incidence in Antwerp, Belgium, 2001–2009. Euro Surveill 2010; 15 (39) 19673
    PubMedGoogle Scholar
  • 21 Barfod TS, Omland LH, Katzenstein TL. Incidence and characteristics of sexually transmitted acute hepatitis C virus infection among HIV-positive men who have sex with men in Copenhagen, Denmark during four years (2006–2009): a retrospective cohort study. Scand J Infect Dis 2011; 43 (2) 145-148
    CrossrefPubMedGoogle Scholar
  • 22 Dionne-Odom J, Osborn MK, Radziewicz H, Grakoui A, Workowski K. Acute hepatitis C and HIV coinfection. Lancet Infect Dis 2009; 9 (12) 775-783
    CrossrefPubMedGoogle Scholar
  • 23 Hull M, Boesecke C. Personal conversation. June 2, 2011
    PubMedGoogle Scholar
  • 24 Remis R. A Study to Characterize the Epidemiology of Hepatitis C Infection in Canada, 2002. Final Report. Public Health Agency of Canada. Available at: http://www.phac-aspc.gc.ca/hepc/pubs/hepc2002/index-eng.php . Accessed October 19, 2011
    PubMedGoogle Scholar
  • 25 Lebanese Republic, Ministry of Public Health. UNGASS Country Progress Report Lebanon March 2010. Available at: http://www.unaids.org/en/dataanalysis/monitoringcountryprogress/2010progressreportssubmittedbycountries/lebanon_2010_country_progress_report_en.pdf. . Accessed October 19, 2011
    PubMedGoogle Scholar
  • 26 Soriano V, Boesecke C, Rockstroh JK. Personal conversation. June 2, 2011
    PubMedGoogle Scholar
  • 27 Boesecke C, Stellbrink HJ, Mauss S , et al. Does baseline HCV genotype have an impact upon treatment outcome of acute HCV infection in HIV co-infected individuals?. Abstract presented at: 18th Conference on Retroviruses and Opportunistic Infections; February 27–March 2, 2011; Boston, MA
    PubMedGoogle Scholar
  • 28 Sun HY, Chang SY, Yang TY , et al. Recent Hepatitis C Virus Infection in HIV-Positive Patients in Taiwan: Incidence and Risk Factors. J Clin Microbiol 2012; 50 (3) 781-787
    CrossrefPubMedGoogle Scholar
  • 29 Lee HC, Ko NY, Lee NY, Chang CM, Ko WC. Seroprevalence of viral hepatitis and sexually transmitted disease among adults with recently diagnosed HIV infection in Southern Taiwan, 2000–2005: upsurge in hepatitis C virus infections among injection drug users. J Formos Med Assoc 2008; 107 (5) 404-411
    CrossrefPubMedGoogle Scholar
  • 30 Larsen C, Alric L, Auperin I , et al. Acute hepatitis C in HIV-infected men who have sex with men in France in 2006 and 2007. Paper presented at: 58th Annual Meeting of the American Association for the Study of the Liver; November 2–6, 2007; Boston, MA
    PubMedGoogle Scholar
  • 31 Clausen LN, Weis N, Astvad K , et al. Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort. J Viral Hepat 2011; 18 (4) e66-e74
    CrossrefPubMedGoogle Scholar
  • 32 van der Helm JJ, Prins M, del Amo J , et al; CASCADE Collaboration. The hepatitis C epidemic among HIV-positive MSM: incidence estimates from 1990 to 2007. AIDS 2011; 25 (8) 1083-1091
    CrossrefPubMedGoogle Scholar
  • 33 Fierer D, Fishman S, Uriel A , et al. Characterization of an outbreak of acute HCV infection in HIV-infected men in New York City. Paper presented at: 16th Conference on Retroviruses and Opportunistic Infections; February 8–11, 2009; Montreal, Canada
    PubMedGoogle Scholar
  • 34 Hung CC, Chen MY, Hsieh SM, Hsiao CF, Sheng WH, Chang SC. Impact of chronic hepatitis C infection on outcomes of patients with an advanced stage of HIV-1 infection in an area of low prevalence of co-infection. Int J STD AIDS 2005; 16 (1) 42-48
    CrossrefPubMedGoogle Scholar
  • 35 Schmidt AJ, Rockstroh JK, Vogel M , et al. Trouble with bleeding: risk factors for acute hepatitis C among HIV-positive gay men from Germany—a case-control study. PLoS ONE 2011; 6 (3) e17781
    CrossrefPubMedGoogle Scholar
  • 36 van de Laar TJ, Paxton WA, Zorgdrager F , et al. Sexual transmission of hepatitis C virus in human immunodeficiency virus-negative men who have sex with men: a series of case reports. Sex Transm Dis 2011; 38 (2) 102-104
    PubMedGoogle Scholar
  • 37 Nguyen O, Sheppeard V, Douglas MW, Tu E, Rawlinson W. Acute hepatitis C infection with evidence of heterosexual transmission. J Clin Virol 2010; 49 (1) 65-68
    CrossrefPubMedGoogle Scholar
  • 38 Marincovich B, Castilla J, del Romero J , et al. Absence of hepatitis C virus transmission in a prospective cohort of heterosexual serodiscordant couples. Sex Transm Infect 2003; 79 (2) 160-162
    CrossrefPubMedGoogle Scholar
  • 39 Vandelli C, Renzo F, Romanò L , et al. Lack of evidence of sexual transmission of hepatitis C among monogamous couples: results of a 10-year prospective follow-up study. Am J Gastroenterol 2004; 99 (5) 855-859
    CrossrefPubMedGoogle Scholar
  • 40 Daniels D, Grytdal S, Wasley A ; Centers for Disease Control and Prevention (CDC). Surveillance for acute viral hepatitis - United States, 2007. MMWR Surveill Summ 2009; 58 (3) 1-27
    PubMedGoogle Scholar
  • 41 Carey JW, Mejia R, Bingham T , et al. Drug use, high-risk sex behaviors, and increased risk for recent HIV infection among men who have sex with men in Chicago and Los Angeles. AIDS Behav 2009; 13 (6) 1084-1096
    CrossrefPubMedGoogle Scholar
  • 42 Thiede H, Jenkins RA, Carey JW , et al. Determinants of recent HIV infection among Seattle-area men who have sex with men. Am J Public Health 2009; 99 (Suppl 1) S157-S164
    CrossrefPubMedGoogle Scholar
  • 43 Götz HM, van Doornum G, Niesters HG, den Hollander JG, Thio HB, de Zwart O. A cluster of acute hepatitis C virus infection among men who have sex with men—results from contact tracing and public health implications. AIDS 2005; 19 (9) 969-974
    CrossrefPubMedGoogle Scholar
  • 44 van de Laar T, Pybus O, Bruisten S , et al. Evidence of a large, international network of HCV transmission in HIV-positive men who have sex with men. Gastroenterology 2009; 136 (5) 1609-1617
    CrossrefPubMedGoogle Scholar
  • 45 Vogel M, van de Laar T, Kupfer B , et al. Phylogenetic analysis of acute hepatitis C virus genotype 4 infections among human immunodeficiency virus-positive men who have sex with men in Germany. Liver Int 2010; 30 (8) 1169-1172
    CrossrefPubMedGoogle Scholar
  • 46 Thomson EC, Nastouli E, Main J , et al. Delayed anti-HCV antibody response in HIV-positive men acutely infected with HCV. AIDS 2009; 23 (1) 89-93
    CrossrefPubMedGoogle Scholar
  • 47 Scott C, Day S, Low E, Sullivan A, Atkins M, Asboe D. Unselected hepatitis C screening of men who have sex with men attending sexual health clinics. J Infect 2010; 60 (5) 351-353
    CrossrefPubMedGoogle Scholar
  • 48 Cicconi P, Cozzi-Lepri A, Phillips A , et al; ICoNA Study Group. Is the increased risk of liver enzyme elevation in patients co-infected with HIV and hepatitis virus greater in those taking antiretroviral therapy?. AIDS 2007; 21 (5) 599-606
    CrossrefPubMedGoogle Scholar
  • 49 Stellbrink HJ, Schewe CK, Vogel M , et al. Increasing numbers of acute hepatitis C infections in HIV-infected MSM and high reinfection rates following SVR. J Int AIDS Soc 2010; 13 (Suppl 4) 200
    PubMedGoogle Scholar
  • 50 Lambers F, Prins M, Thomas X , et al. High incidence rate of HCV reinfection after treatment of acute HCV infection in HIV-infected MSM in Amsterdam. Poster presented at: 18th Conference on Retroviruses and Opportunistic Infections; February 27–March 2, 2011; Boston, MA
    PubMedGoogle Scholar
  • 51 Grebely J, Petoumenos K, Hellard M , et al; ATAHC Study Group. Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection. Hepatology 2010; 52 (4) 1216-1224
    CrossrefPubMedGoogle Scholar
  • 52 Jones L, Uriel A, Kaplan D , et al. Natural history and treatment outcome of acute hepatitis C with and without HIV co-infection in a North American cohort. Paper presented at: 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD 2008); October 31–November 4, 2008; San Francisco, CA
    PubMedGoogle Scholar
  • 53 Thomson EC, Fleming VM, Main J , et al. Predicting spontaneous clearance of acute hepatitis C virus in a large cohort of HIV-1-infected men. Gut 2011; 60 (6) 837-845
    CrossrefPubMedGoogle Scholar
  • 54 Thomas DL, Astemborski J, Rai RM , et al. The natural history of hepatitis C virus infection: host, viral, and environmental factors. JAMA 2000; 284 (4) 450-456
    CrossrefPubMedGoogle Scholar
  • 55 Gilleece YC, Browne RE, Asboe D , et al. Transmission of hepatitis C virus among HIV-positive homosexual men and response to a 24-week course of pegylated interferon and ribavirin. J Acquir Immune Defic Syndr 2005; 40 (1) 41-46
    CrossrefPubMedGoogle Scholar
  • 56 Thomson EC, Fleming VM, Main J , et al. Predicting spontaneous clearance of acute hepatitis C virus in a large cohort of HIV-1-infected men. Gut 2011; 60 (6) 837-845
    CrossrefPubMedGoogle Scholar
  • 57 Thomas DL, Thio CL, Martin MP , et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 2009; 461 (7265) 798-801
    CrossrefPubMedGoogle Scholar
  • 58 Rauch A, Kutalik Z, Descombes P , et al. Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. Gastroenterology 2010; 138 (4) 1338-1345 , 1345.e1–e7
    CrossrefPubMedGoogle Scholar
  • 59 Ge D, Fellay J, Thompson AJ , et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009; 461 (7262) 399-401
    CrossrefPubMedGoogle Scholar
  • 60 Fierer DS, Uriel AJ, Carriero DC , et al. Liver fibrosis during an outbreak of acute hepatitis C virus infection in HIV-infected men: a prospective cohort study. J Infect Dis 2008; 198 (5) 683-686
    CrossrefPubMedGoogle Scholar
  • 61 Vogel M, Page E, Boesecke C , et al. Liver fibrosis progression after acute HCV infection (AHC) in HIV-positive individuals. Clin Infect Dis 2012; 54 (4) 556-9
    CrossrefPubMedGoogle Scholar
  • 62 Vogel M, Boesecke C, Rockstroh JK. Acute hepatitis C infection in HIV-positive patients. Curr Opin Infect Dis 2011; 24 (1) 1-6
    PubMedGoogle Scholar
  • 63 Vogel M, Page E, Matthews G , et al. Use of week 4 HCV RNA after acute HCV infection to predict chronic HCV infection. Paper presented at: 17th Conference on Retroviruses and Opportunistic Infections; February 16–19, 2010; San Francisco, CA
    PubMedGoogle Scholar
  • 64 Gerlach JT, Diepolder HM, Zachoval R , et al. Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance. Gastroenterology 2003; 125 (1) 80-88
    CrossrefPubMedGoogle Scholar
  • 65 Deterding K, Gruner NH, Wiegand J , et al. Early versus delayed treatment of acute hepatitis C: the German HEP-NET Acute HCV-III Study—a randomized controlled trial. 44th Annual Meeting of the European Association for the Study of the Liver (EASL 2009); April 27–26, 2009; Copenhagen, Denmark
    PubMedGoogle Scholar
  • 66 Dore GJ, Hellard M, Matthews GV , et al. Effective treatment of injecting drug users with recently acquired hepatitis C virus infection. Gastroenterology 2010; 138 (1) 123-135.e2
    CrossrefPubMedGoogle Scholar
  • 67 Boesecke C, Rockstroh JK. Treatment of acute hepatitis C infection in HIV-infected patients. Curr Opin HIV AIDS 2011; 6 (4) 278-284
    CrossrefPubMedGoogle Scholar
  • 68 The European AIDS Treatment Network (NEAT) Acute Hepatitis C Infection Consensus Panel. Acute hepatitis C in HIV-infected individuals: recommendations from the European AIDS Treatment Network (NEAT) consensus conference. AIDS 2011; 25 (4) 399-409
    PubMedGoogle Scholar
  • 69 Vogel M, Nattermann J, Baumgarten A , et al. Pegylated interferon-alpha for the treatment of sexually transmitted acute hepatitis C in HIV-infected individuals. Antivir Ther 2006; 11 (8) 1097-1101
    PubMedGoogle Scholar
  • 70 Schnuriger A, Dominguez S, Guiguet M , et al. Acute hepatitis C in HIV-infected patients: rare spontaneous clearance correlates with weak memory CD4 T-cell responses to hepatitis C virus. AIDS 2009; 23 (16) 2079-2089
    CrossrefPubMedGoogle Scholar
  • 71 Dominguez S, Ghosn J, Valantin MA , et al. Efficacy of early treatment of acute hepatitis C infection with pegylated interferon and ribavirin in HIV-infected patients. AIDS 2006; 20 (8) 1157-1161
    CrossrefPubMedGoogle Scholar
  • 72 Kruk A. Efficacy of acute HCV treatment with peg-interferon alfa-2b and ribavirin in HIV-infected patients. Paper presented at: 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment; July 24–27, 2005; Rio de Janeiro, Brazil
    PubMedGoogle Scholar
  • 73 Serpaggi J, Chaix ML, Batisse D , et al. Sexually transmitted acute infection with a clustered genotype 4 hepatitis C virus in HIV-1-infected men and inefficacy of early antiviral therapy. AIDS 2006; 20 (2) 233-240
    CrossrefPubMedGoogle Scholar
  • 74 Piroth L, Larsen C, Binquet C , et al; Steering Committee of the HEPAIG Study. Treatment of acute hepatitis C in human immunodeficiency virus-infected patients: the HEPAIG study. Hepatology 2010; 52 (6) 1915-1921
    CrossrefPubMedGoogle Scholar
  • 75 Núñez M, Miralles C, Berdún MA , et al; PRESCO Study Group. Role of weight-based ribavirin dosing and extended duration of therapy in chronic hepatitis C in HIV-infected patients: the PRESCO trial. AIDS Res Hum Retroviruses 2007; 23 (8) 972-982
    CrossrefPubMedGoogle Scholar
  • 76 Vogel M, Ahlenstiel G, Hintsche B , et al. The influence of HAART on the efficacy and safety of pegylated interferon and ribavirin therapy for the treatment of chronic HCV infection in HIV-positive Individuals. Eur J Med Res 2010; 15 (3) 102-111
    PubMedGoogle Scholar
  • 77 Arends J, Mudrikova T, Wensing A , et al. High percentage of non-response with peginterferon-alfa-2a monotherapy for the treatment of acute hepatitis C in HIV infected patients. Paper presented at: 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2009);September 12–15, 2009; San Francisco, CA
    PubMedGoogle Scholar
  • 78 Matthews G, Grebely J, Hellard M , et al. Differences in early virological decline in individuals treated within the Australian trial in acute HCV suggest a potential benefit for the use of ribavirin. Paper presented at: 45th Annual Meeting of the European Association for the Study of the Liver (EASL); April 14–18, 2010; Vienna, Austria
    PubMedGoogle Scholar
  • 79 Hare B, Marks K, Luetkemeyer A , et al. Kinetically guided PEG Alfa-2a and RBV therapy for HIV+ adults with acute HCV infection. Paper presented at: 17th Conference on Retroviruses and Opportunistic Infection; February 16–19, 2010; San Francisco, CA
    PubMedGoogle Scholar
  • 80 Hare B, Marks K, Luetkemeyer A , et al. Kinetically guided PEG Alfa-2a and RBV therapy for HIV+ adults with acute HCV infection. Paper presented at: 18th Conference on Retroviruses and Opportunistic Infection; February 27–March 2, 2011; Boston, MA
    PubMedGoogle Scholar
  • 81 Nattermann J, Vogel M, Nischalke HD , et al. Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C. J Infect Dis 2011; 203 (5) 595-601
    CrossrefPubMedGoogle Scholar
  • 82 Vogel M, Dominguez S, Bhagani S , et al. Treatment of acute HCV infection in HIV-positive patients: experience from a multicentre European cohort. Antivir Ther 2010; 15 (2) 267-279
    CrossrefPubMedGoogle Scholar
  • 83 Lambers F, Brinkman K, Schinkel J , et al. Treatment of acute hepatitis C virus infection in HIV-infected MSM: the effect of treatment duration. AIDS 2011; 19;25 (10) 1333-1336
    PubMedGoogle Scholar
  • 84 Matthews GV, Dore GJ. Optimal duration of treatment for acute hepatitis C in human immunodeficiency virus-positive individuals?. Hepatology 2011; 53 (3) 1055-1056 , author reply 1056–1057
    PubMedGoogle Scholar
  • 85 Dorward J, Garrett N, Scott D , et al. Successful treatment of acute hepatitis C virus in HIV positive patients using the European AIDS Treatment Network guidelines for treatment duration. J Clin Virol 2011; 52 (4) 367-369
    CrossrefPubMedGoogle Scholar
  • 86 Carlsson T, Quist A, Weiland O. Rapid viral response and treatment outcome in genotype 2 and 3 chronic hepatitis C: comparison between two HCV RNA quantitation methods. J Med Virol 2008; 80 (5) 803-807
    CrossrefPubMedGoogle Scholar