Simple Ultrasound-Assisted Synthesis of 3,4-Dihydropyrimidin-2(1H)-one and 3,4-Dihydropyrimidine-2(1H)-thione-Fused Steroidal Derivatives by a Three-Component Reaction

Mandakini Dutta; Junali Gogoi; Kommoori Shekarrao; Jonalee Goswami; Sanjib Gogoi; Romesh Chandra Boruah

doi:10.1055/s-0032-1316564

Synthesis, Inhaltsverzeichnis

Synthesis 2012; 44(16): 2614-2622
DOI: 10.1055/s-0032-1316564

paper

Simple Ultrasound-Assisted Synthesis of 3,4-Dihydropyrimidin-2(1H)-one and 3,4-Dihydropyrimidine-2(1H)-thione-Fused Steroidal Derivatives by a Three-Component Reaction

Mandakini Dutta

Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India, Fax: +91(376)2370011 eMail: skgogoi1@gmail.com eMail: rc_boruah@yahoo.co.in

,

Junali Gogoi

Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India, Fax: +91(376)2370011 eMail: skgogoi1@gmail.com eMail: rc_boruah@yahoo.co.in

,

Kommoori Shekarrao

Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India, Fax: +91(376)2370011 eMail: skgogoi1@gmail.com eMail: rc_boruah@yahoo.co.in

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Jonalee Goswami

Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India, Fax: +91(376)2370011 eMail: skgogoi1@gmail.com eMail: rc_boruah@yahoo.co.in

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Sanjib Gogoi*

Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India, Fax: +91(376)2370011 eMail: skgogoi1@gmail.com eMail: rc_boruah@yahoo.co.in

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Romesh Chandra Boruah*

Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India, Fax: +91(376)2370011 eMail: skgogoi1@gmail.com eMail: rc_boruah@yahoo.co.in

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Abstract

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Abstract

Compounds containing fused 3,4-dihydropyrimidin-2(1H)-one or 3,4-dihydropyrimidine-2(1H)-thione moieties were prepared by three-component reactions of a steroidal or nonsteroidal ketone, an alkyl or aryl aldehyde, and urea or thiourea in the presence of sodium ethoxide. The products were isolated in good yields after short reaction times under mild conditions.

Key words

steroids - heterocycles - multicomponent reactions - ultrasound

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Referenzen

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