Synthetic Studies toward Ecteinascidin 743 (Trabectedin)

Abstract

An alternative synthetic route to an intermediate in the synthesis of ecteinascidin 743 has been established by using a Pictet–Spengler reaction and a Friedel–Crafts type reaction.

Key words

alkaloids - anticancer drugs - Pictet–Spengler reaction - Friedel–Crafts reaction - total synthesis

• References

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