Microwave-Assisted Click Chemistry Synthesis of 1,2,3-Triazoles from Aryldiazonium Silica Sulfates in Water

Amin Zarei; Leila Khazdooz; Abdol R. Hajipour; Hamidreza Aghaei; Ghobad Azizi

doi:10.1055/s-0032-1316783

Synthesis, Table of Contents

Synthesis 2012; 44(21): 3353-3360
DOI: 10.1055/s-0032-1316783

paper

Microwave-Assisted Click Chemistry Synthesis of 1,2,3-Triazoles from Aryldiazonium Silica Sulfates in Water

Amin Zarei*

^aDepartment of Science, Fasa Branch, Islamic Azad University, PO Box 364, Fasa 7461713591, Fars, Iran Fax: +98(311)2289113 Email: aj_zarei@yahoo.com

,

Leila Khazdooz

^bDepartment of Science, Khorasgan Branch, Islamic Azad University, Isfahan 81595158, Iran

,

Abdol R. Hajipour

^cPharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan 84156, Iran

^dDepartment of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, WI 53706-1532, USA

,

Hamidreza Aghaei

^eDepartment of Chemistry, Shahreza Branch, Islamic Azad University, Shahreza 31186145, Isfahan, Iran

,

Ghobad Azizi

^dDepartment of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, WI 53706-1532, USA

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Abstract

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Abstract

A microwave-assisted click chemistry synthesis of 1,4-disubstituted 1,2,3-triazoles is studied by in situ generation of aryl azides via the reaction of aryldiazonium silica sulfates and sodium azide, followed by coupling with a terminal alkyne in the presence of copper catalyst. These reactions are carried out in water under mild and heterogeneous conditions without using any additional ligands.

Key words

aryldiazonium silica sulfates - click reaction - 1,2,3-triazoles - microwave irradiation

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References

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