Abstract
This review covers advances in the synthesis of morpholin-3-ones and morpholin-2-ones. Besides the classical approaches for the preparation of both heterocycles that utilize intermolecular cyclizations of reactants or oxidation of morpholine and its derivatives, strategies employing various ring-expansion reactions using smaller heterocyclic substrates or multicomponent reactions are described.
1 Introduction
2 Synthesis of Morpholin-3-ones
2.1 By Formation of Two Bonds
2.2 By Formation of One Bond
2.3 By Introduction of Substituents
3 Synthesis of Morpholin-2-ones
3.1 By Formation of Two Bonds
3.2 By Formation of One Bond
3.3 By Introduction of Substituents
4 Conclusion
Key words
morpholin-3-one - morpholin-2-one - one-bond cyclization - two-bond cyclization - heterocycle oxidation
