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Synthesis 2012; 44(24): 3757-3764
DOI: 10.1055/s-0032-1316810
DOI: 10.1055/s-0032-1316810
paper
Stereospecific Synthesis and Biological Evaluation of Monodesmethyl Metabolites of (+)-13a-(S)-Deoxytylophorinine as Potential Antitumor Agents
Further Information
Publication History
Received: 09 September 2012
Accepted after revision: 24 October 2012
Publication Date:
09 November 2012 (online)
Abstract
Three major monodesmethyl metabolites of (+)-13a-(S)-deoxytylophorinine were synthesized stereospecifically and their configurations at C-13a were determined. Biological assays revealed that one of the metabolites, 3-O-desmethyl-13a-(S)-deoxytylophorinine, had a higher cytotoxic potency than the parent compound or the positive controls doxorubicin (Adriamycin) and paclitaxel (Taxol).
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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