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Synthesis 2013; 45(1): 45-52
DOI: 10.1055/s-0032-1316821
DOI: 10.1055/s-0032-1316821
paper
An Efficient Synthesis of 2-Aminothiophenes via the Gewald Reaction Catalyzed by an N-Methylpiperazine-Functionalized Polyacrylonitrile Fiber
Authors
Further Information
Publication History
Received: 12 September 2012
Accepted after revision: 09 November 2012
Publication Date:
29 November 2012 (online)
Abstract
A new N-methylpiperazine-functionalized polyacrylonitrile fiber has been developed to catalyze the Gewald reaction between 2,5-dihydroxy-1,4-dithiane and activated nitriles to afford 3-substituted 2-aminothiophenes in good to excellent yields (65–91%). Low catalyst loading (8.0 mol%), simple procedure, high yields, excellent recyclability, and reusability (up to 10 times with minimal loss of catalytic activity) are attractive features of this fiber catalyst.
Key words
Gewald reaction - 2-aminothiophene - N-methylpiperazine - polyacrylonitrile fiber - fiber catalystSupporting Information
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