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Synthesis 2013; 45(2): 265-271
DOI: 10.1055/s-0032-1316825
DOI: 10.1055/s-0032-1316825
paper
Efficient Multigram Syntheses of Air-Stable, Chiral Primary Phosphine Ligand Precursors via Palladium-Catalyzed Phosphonylation of Aryltriflates
Further Information
Publication History
Received: 25 September 2012
Accepted after revision: 14 November 2012
Publication Date:
13 December 2012 (online)
Abstract
Air-stable, chiral primary phosphines have been synthesized on a multigram scale. The key synthetic step is an optimized palladium-catalyzed phosphonylation reaction of aryltriflates, which opens up a valuable synthetic route to a chiral scaffold that is easily derivatized into novel phosphines.
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