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Synthesis 2013; 45(1): 85-92
DOI: 10.1055/s-0032-1316828
DOI: 10.1055/s-0032-1316828
paper
Efficient Synthesis of Imidazole-Fused Benzodiazepines Using Palladium-Catalyzed Intramolecular C–N Bond Formation Reaction
Further Information
Publication History
Received: 07 November 2012
Accepted after revision: 26 November 2012
Publication Date:
06 December 2012 (online)
Abstract
An efficient three-step synthetic route to imidazole-fused benzodiazepines from imidazole-2-carbaldehyde is described. Application of intramolecular Buchwald–Hartwig cycloamination reaction in the final step is shown to be a convenient method for the synthesis of fused seven-membered diazacycles. The reactions proceeded smoothly with both aliphatic and aromatic amines.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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