Highly Enantioselective Three-Component Reactions of tert-Butyl Diazoacetate with Arylamines and Imines: An Efficient Synthesis of α,β-Bis(arylamino) Acid Derivatives

Abstract

Enantioselective three-component reactions of tert-butyl diazoacetate with arylamines and imines afford α,β-bis(arylamino) acid derivatives in good yields (56–90%) with high diastereoselectivities (up to >95:5 dr) and excellent enantioselectivities (up to 96% ee).

Key words

multicomponent reaction - tert-butyl diazoacetate - ammonium ylide - imine addition - α,β-diamino acids

• References

• 1 Liqin Jiang and Dan Zhang contributed equally to this work.
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