The outstanding usefulness of phenol-derived chiral phosphine–phosphite ligands has recently been shown in a number of transition-metal-catalyzed C–C bond-forming reactions. This is exemplified by the synthesis of five new ligands in an optimized procedure that can be reliably performed on a multigram scale.
Key words
Chiral P,P-ligands - enantioselective catalysis - bromine–lithium exchange - synthetic methods - asymmetric 1,4-addition