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Synthesis 2013; 45(7): 936-942
DOI: 10.1055/s-0032-1316868
DOI: 10.1055/s-0032-1316868
paper
A Convenient One-Pot Synthesis of N-Substituted 2-Aminoazole Derivatives
Weitere Informationen
Publikationsverlauf
Received: 22. Januar 2013
Accepted after revision: 18. Februar 2013
Publikationsdatum:
08. März 2013 (online)
Abstract
A practical protocol for the one-pot synthesis of N-substituted 2-aminoazole derivatives is described, employing simple azole substrates, nitrogen nucleophiles, lithium tert-butoxide as the base, and iodine to mediate carbon–nitrogen bond formation. This method proceeds at room temperature under an air atmosphere using a normal benchtop set-up, or can be performed conveniently using microwave irradiation.
Key words
N-substituted 2-aminoazoles - iodine - one-pot synthesis - benzoxazole - carbon–nitrogen bond formationSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
-
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Selected literature:
Selected references on natural products or biologically active molecules that contain substituted 1,3-azoles. Imidazoles:
Thiazoles:
Oxazoles: