Synthesis of 4-Alkynyl-1,2-dimethyl-5-nitro-1H-imidazoles via Microwave-Assisted Sonogashira Cross-Coupling Reactions

Kevin Neildé; Maxime D. Crozet; Thierry Terme; Patrice Vanelle

doi:10.1055/s-0032-1316907

Synthesis, Table of Contents

Synthesis 2013; 45(10): 1349-1356
DOI: 10.1055/s-0032-1316907

paper

Synthesis of 4-Alkynyl-1,2-dimethyl-5-nitro-1H-imidazoles via Microwave-Assisted Sonogashira Cross-Coupling Reactions

Kevin Neildé

Aix-Marseille Université, UMR CNRS 7273: Institut de Chimie Radicalaire, Equipe Pharmaco-Chimie Radicalaire (LPCR), Faculté de Pharmacie, 27 Boulevard Jean Moulin, CS 30064, 13385 Marseille Cedex 5, France Fax: +33(4)86136822 Email: patrice.vanelle@univ-amu.fr

,

Maxime D. Crozet

Aix-Marseille Université, UMR CNRS 7273: Institut de Chimie Radicalaire, Equipe Pharmaco-Chimie Radicalaire (LPCR), Faculté de Pharmacie, 27 Boulevard Jean Moulin, CS 30064, 13385 Marseille Cedex 5, France Fax: +33(4)86136822 Email: patrice.vanelle@univ-amu.fr

,

Thierry Terme

Aix-Marseille Université, UMR CNRS 7273: Institut de Chimie Radicalaire, Equipe Pharmaco-Chimie Radicalaire (LPCR), Faculté de Pharmacie, 27 Boulevard Jean Moulin, CS 30064, 13385 Marseille Cedex 5, France Fax: +33(4)86136822 Email: patrice.vanelle@univ-amu.fr

,

Patrice Vanelle*

Aix-Marseille Université, UMR CNRS 7273: Institut de Chimie Radicalaire, Equipe Pharmaco-Chimie Radicalaire (LPCR), Faculté de Pharmacie, 27 Boulevard Jean Moulin, CS 30064, 13385 Marseille Cedex 5, France Fax: +33(4)86136822 Email: patrice.vanelle@univ-amu.fr

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Abstract

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Abstract

A new, simple, rapid and moderate to high yielding synthesis of various 4-alkynyl-1,2-dimethyl-5-nitro-1H-imidazoles via Sonogashira palladium-catalyzed cross-coupling using microwave irradiation is described.

Key words

nitroimidazole - Sonogashira reaction - palladium - cross-coupling - microwave irradiation

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References

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