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Synthesis 2013; 45(15): 2101-2108
DOI: 10.1055/s-0032-1316921
DOI: 10.1055/s-0032-1316921
special topic
Rhodium-Catalyzed Asymmetric Amination of Allylic Trichloroacetimidates
Further Information
Publication History
Received: 22 February 2013
Accepted after revision: 20 March 2013
Publication Date:
30 April 2013 (online)
Abstract
A summary is presented of dynamic kinetic asymmetric transformations of racemic allylic trichloroacetimidates in the presence of chiral diene-ligated rhodium catalysts. The reaction is applicable to a wide variety of secondary and tertiary trichloroacetimidates containing aniline or benzylamine nucleophiles, affording nitrogen-containing tertiary and quaternary centers in good yields and with high levels of regio- and enantioselectivity. This catalytic method addresses many of the limitations previously associated with syntheses of these compounds.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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