Synthesis of Polysubstituted Naphthalenes by Iron-Catalyzed [2+2+2] Annu­lation of Grignard Reagents with Alkynes

Abstract

Iron catalyzes the oxidative [2+2+2] annulation of an ­arylmagnesium compound with two molecules of an internal alkyne via C–H bond activation at 0 °C to produce polysubstituted naphthalene.

Key words

alkynes - annulation - C–H bond activation - iron - naphthalene

• References and Notes

• 1 Current address: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore
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