Synlett, Inhaltsverzeichnis Synlett 2012; 23(19): 2777-2784DOI: 10.1055/s-0032-1317505 letter © Georg Thieme Verlag Stuttgart · New York Bis(phosphinite) with C 2-Symmetric Axis; Effects on the Ruthenium(II)- Catalyzed Asymmetric Transfer Hydrogenation of Acetophenone Derivatives Murat Aydemir* Dicle University, Department of Chemistry, 21280 Diyarbakır, Turkey Fax: +90(412)2488300 eMail: aydemir@dicle.edu.tr , Feyyaz Durap Dicle University, Department of Chemistry, 21280 Diyarbakır, Turkey Fax: +90(412)2488300 eMail: aydemir@dicle.edu.tr , Cezmi Kayan Dicle University, Department of Chemistry, 21280 Diyarbakır, Turkey Fax: +90(412)2488300 eMail: aydemir@dicle.edu.tr , Akin Baysal Dicle University, Department of Chemistry, 21280 Diyarbakır, Turkey Fax: +90(412)2488300 eMail: aydemir@dicle.edu.tr , Yılmaz Turgut Dicle University, Department of Chemistry, 21280 Diyarbakır, Turkey Fax: +90(412)2488300 eMail: aydemir@dicle.edu.tr › Institutsangaben Artikel empfehlen Abstract Artikel einzeln kaufen Alle Artikel dieser Rubrik Abstract Chiral ruthenium catalyst systems generated in situ from [Ru(η6-p-cymene)(μ-Cl)Cl]2 complex and chiral C 2-symmetric bis(phosphinite) ligands based on amino alcohol derivatives were employed in the asymmetric transfer hydrogenation of aromatic ketones to give the corresponding optically active alcohols in high yield. The best results were obtained in the [Ru(η6-p-cymene)(μ-Cl)Cl]2 and (2S)-2-[benzyl(2-{benzyl[(2S)-1-[(diphenylphosphanyl)oxy]-3-phenyl propan-2-yl]amino}ethyl)amino]-3-phenylpropyl diphenylphosphinite or (2R)-2-[benzyl(2-{benzyl[(2R)-1-[(diphenylphosphanyl)oxy]-3-phenylpropan-2-yl]amino}ethyl)amino]-3-phenylpropyl diphenylphosphinite catalytic systems, which gave enantioselectivities of up to 93% ee and 99% conversion. Key words Key wordsphosphinites - enantioselectivity - hydrogenation - homogeneous catalysis - ruthenium - ketones Volltext Referenzen References and Notes 1 Li X, Wu X, Chen W, Hancock FE, King F, Xiao J. Org. Lett. 2004; 19: 3321 2 Everaere K, Mortreux A, Carpentier JF. Adv. Synth. Catal. 2003; 345: 67 3 Fan QH, Li YM, Chan AS. C. Chem. Rev. 2002; 102: 3385 4 Blaser HU, Malan C, Pugin B, Spindler F, Steiner H, Studer M. Adv. Synth. Catal. 2003; 345: 103 5 Noyori R, Ohkuma T. Angew. Chem. Int. Ed. 2001; 40: 40 6 Takaha H, Ohta T, Noyori R. 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