Synthesis of Nucleo Aminooxy Acid Derivatives

Olivier Noel; Juan Xie

doi:10.1055/s-0032-1317689

Synthesis, Table of Contents

Synthesis 2013; 45(1): 134-140
DOI: 10.1055/s-0032-1317689

paper

Synthesis of Nucleo Aminooxy Acid Derivatives

Olivier Noel

PPSM, ENS Cachan, Institut d’Alembert, CNRS, UMR 8531, 61 av. Président Wilson, 94235 Cachan cedex, France Fax: +33(1)47402454 Email: joanne.xie@ens-cachan.fr

,

Juan Xie*

PPSM, ENS Cachan, Institut d’Alembert, CNRS, UMR 8531, 61 av. Président Wilson, 94235 Cachan cedex, France Fax: +33(1)47402454 Email: joanne.xie@ens-cachan.fr

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Abstract

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Abstract

Nucleobase-functionalized peptides have attracted increasing interest because of their well-ordered secondary structures and stability toward enzymatic degradations. We have designed and synthesized nucleo aminooxy acids as novel building blocks for nucleopeptides. Four nucleo aminooxy acid derivatives with cytosine or thymine in the side chain linked by an amide or a triazole moiety have been synthesized from l-serine.

Key words

nucleo aminooxy acids - nucleopeptides - N-oxy nucleopeptides - cytosine - thymine - amides - triazoles - l-serine - eliminations

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References

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