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Synthesis 2013; 45(2): 167-170
DOI: 10.1055/s-0032-1317698
DOI: 10.1055/s-0032-1317698
practical synthetic procedures
An Expedient Access to Still–Gennari Phosphonates
Weitere Informationen
Publikationsverlauf
Received: 03. Oktober 2012
Accepted after revision: 31. Oktober 2012
Publikationsdatum:
20. November 2012 (online)
Abstract
An inexpensive and efficient route to the Still–Gennari phosphonates, methyl and ethyl bis(2,2,2-trifluoroethyl)phosphonoacetates, has been developed. This short reaction sequence is operationally simple and makes these versatile reagents for the preparation of Z-alkenes, according to the Still–Gennari modification of the Horner–Wadsworth–Emmons olefination reaction, available in multigram quantities.
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