Studies toward the Total Synthesis of Carolacton

Abstract

An efficient synthesis of the C1–C19 segment of carolacton is described, starting from d-ribose, (–)-β-citronellene and a homopropargylic alcohol, and which employs a Nozaki–Hiyama–Kishi (NHK) coupling as the key step. Other important steps are cross-metathesis and Evans aldol reactions.

Key words

carolacton - macrolide - Evans aldol - Nozaki–Hiyama–Kishi coupling - cross-metathesis

• References

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