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Synthesis 2013; 45(1): 101-105
DOI: 10.1055/s-0032-1317707
DOI: 10.1055/s-0032-1317707
paper
The First Practical Additive-Free 1,4-Conjugated Alkylation of Fluoroalkylated Electron-Deficient Olefins with Various Organozinc Reagents
Weitere Informationen
Publikationsverlauf
Received: 30. September 2012
Accepted after revision: 08. November 2012
Publikationsdatum:
27. November 2012 (online)


Abstract
1,4-Conjugated alkylation of fluoroalkylated olefins with organozinc reagents, such as RZnI and R2Zn, was conducted smoothly to give the corresponding products in moderate yields without the use of either transition metals or Lewis acids. This reaction protocol allows not only a wide range of alkyl groups but also electron-withdrawing groups to be incorporated as 1,4-conjugated adducts.
Key words
1,4-conjugated alkylation - organozinc reagents - trifluoromethyl - electron-deficient olefinSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information