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Synlett 2013; 24(1): 105-113
DOI: 10.1055/s-0032-1317761
letter
© Georg Thieme Verlag Stuttgart · New York

Studies on Novel Synthetic Methodologies, Part XII: An Efficient One-Pot Access to 6,6a-Dihydroisoindolo[2,1-a]quinazoline-5,11-diones and 5-Phenylisoindolo[2,1-a]quinazolin-11(6aH)-ones

Koneni V. Sashidhara*
a   Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR-CDRI, Lucknow 226001, India   Fax: +91(522)2623405   Email: sashidhar123@gmail.com   Email: kv_sashidhara@cdri.res.in
,
Gopala Reddy Palnati
a   Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR-CDRI, Lucknow 226001, India   Fax: +91(522)2623405   Email: sashidhar123@gmail.com   Email: kv_sashidhara@cdri.res.in
,
Ranga Prasad Dodda
a   Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR-CDRI, Lucknow 226001, India   Fax: +91(522)2623405   Email: sashidhar123@gmail.com   Email: kv_sashidhara@cdri.res.in
,
Srinivasa Rao Avula
a   Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR-CDRI, Lucknow 226001, India   Fax: +91(522)2623405   Email: sashidhar123@gmail.com   Email: kv_sashidhara@cdri.res.in
,
Priyanka Swami
b   Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli 229010, India
› Author Affiliations
Further Information

Publication History

Received: 26 October 2012

Accepted after revision: 15 November 2012

Publication Date:
11 December 2012 (online)

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Abstract

A simple and efficient procedure for the construction of 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione and 5-phenylisoindolo[2,1-a]quinazolin-11(6aH)-one derivatives in acetic acid under catalyst-free conditions is described. Attractive features of this methodology are its versatility, ready availability of starting materials and the efficiency in creating a complex core in a single operation.

Key words

one-pot synthesis - catalyst-free - 6,6a-dihydroiso­indolo[2,1-a]quinazoline-5,11-dione - 5-phenylisoindolo[2,1-a]quinazolin-11(6aH)-one - 2-formyl benzoic acid

Supporting Information

    for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
  • Supporting Information
 

  • References and Notes

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