A User-Friendly Procedure for the Preparation of Secondary Alkyl Chlorides

Abstract

Secondary alkyl chlorides have been efficiently prepared from secondary alkyl sulfonates under mild and user-friendly conditions. The exchange reaction was generally performed by using benzyltributylammonium chloride in acetone (reflux, 30 min). Yields are excellent from functionalized, base-sensitive and hindered secondary alkyl sulfonates.

Key words

nucleophilic substitution - sulfonates - secondary alkyl chlorides - quaternary ammonium halides - sulfonate–halogen exchange

• References


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