A Reliable Synthesis of 3-Amino-5-Alkyl and 5-Amino-3-Alkyl Isoxazoles

Leland Johnson; James Powers; Fupeng Ma; Keith Jendza; Bing Wang; Erik Meredith; Nello Mainolfi

doi:10.1055/s-0032-1317935

Synthesis, Table of Contents

Synthesis 2013; 45(2): 171-173
DOI: 10.1055/s-0032-1317935

short paper

A Reliable Synthesis of 3-Amino-5-Alkyl and 5-Amino-3-Alkyl Isoxazoles

Leland Johnson

Novartis Institutes for Biomedical Research, Global Discovery Chemistry, 100 Technology Square, Cambridge, MA 02139, USA Fax: +1(617)8717044 Email: nello.mainolfi@novartis.com

,

James Powers

Novartis Institutes for Biomedical Research, Global Discovery Chemistry, 100 Technology Square, Cambridge, MA 02139, USA Fax: +1(617)8717044 Email: nello.mainolfi@novartis.com

,

Fupeng Ma

Novartis Institutes for Biomedical Research, Global Discovery Chemistry, 100 Technology Square, Cambridge, MA 02139, USA Fax: +1(617)8717044 Email: nello.mainolfi@novartis.com

,

Keith Jendza

Novartis Institutes for Biomedical Research, Global Discovery Chemistry, 100 Technology Square, Cambridge, MA 02139, USA Fax: +1(617)8717044 Email: nello.mainolfi@novartis.com

,

Bing Wang

Novartis Institutes for Biomedical Research, Global Discovery Chemistry, 100 Technology Square, Cambridge, MA 02139, USA Fax: +1(617)8717044 Email: nello.mainolfi@novartis.com

,

Erik Meredith

Novartis Institutes for Biomedical Research, Global Discovery Chemistry, 100 Technology Square, Cambridge, MA 02139, USA Fax: +1(617)8717044 Email: nello.mainolfi@novartis.com

,

Nello Mainolfi*

Novartis Institutes for Biomedical Research, Global Discovery Chemistry, 100 Technology Square, Cambridge, MA 02139, USA Fax: +1(617)8717044 Email: nello.mainolfi@novartis.com

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Abstract

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Abstract

A reliable procedure that can be used to access a wide range of 3-amino-5-alkyl and 5-amino-3-alkyl isoxazoles was developed. Reaction temperature and pH were key factors that determined the regioselectivity of the two reactions.

Key words

heterocycles - regioselectivity - condensation - medicinal chemistry - imines

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References

References

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