Stereoselective Synthesis of the C10–C18 Fragment of Iriomoteolide-3a

Abstract

An efficient synthesis of the highly stereogenic centered C10–C18 fragment of iriomoteolide-3a has been accomplished. Key steps include Sharpless asymmetric dihydroxylation and epoxidation for generation of the desired stereocenters.

Key words

macrolide - total synthesis - iriomoteolide-3a - ortho-Claisen rearrangement - Sharpless dihydroxylation

• References

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