Synthesis 2013; 45(6): 767-772
DOI: 10.1055/s-0032-1318148
paper
© Georg Thieme Verlag Stuttgart · New York

Macrocyclic Peptoids by Selective S-Acylation of Cysteine Esters

Mohamed A. Ibrahim
a   Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
b   Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt
c   Department of Organic Chemistry, College of Pharmacy, Misr University for Science and Technology, P.O. Box 77, Al-Motamayez District, 6th of October City, Egypt
,
Siva S. Panda
a   Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
,
Linda Nhon
a   Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
,
Ahmed Hamed
a   Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
,
Said A. El-Feky
b   Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt
,
Alan R. Katritzky*
a   Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
d   Chemistry Department, King Abdulaziz University, Jeddah 21589, Saudi Arabia   Fax: +1(352)3929199   eMail: katritzky@chem.ufl.edu
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Publikationsverlauf

Received: 02. November 2012

Accepted after revision: 10. Januar 2013

Publikationsdatum:
21. Februar 2013 (online)


Abstract

Optimized selective S-acylations of cysteine esters gave intermediates for the synthesis of macrocyclic peptoids by a benzotriazole-based method.

Supporting Information