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Synthesis 2013; 45(5): 678-682
DOI: 10.1055/s-0032-1318149
DOI: 10.1055/s-0032-1318149
paper
Click Chemistry with 2-Ethynyl-4,5,6,7-tetrahydroindoles: Towards Functionalized Tetrahydroindole-Triazole Ensembles
Authors
Weitere Informationen
Publikationsverlauf
Received: 02. Dezember 2012
Accepted after revision: 11. Januar 2013
Publikationsdatum:
01. Februar 2013 (online)
Abstract
2-Ethynyl-4,5,6,7-tetrahydroindoles, readily available from 4,5,6,7-tetrahydroindoles and bromoacetylenes on K2CO3, when treated with sodium azide in DMSO, afford functionalized tetrahydroindole-triazoles ensembles. The reaction proceeds under mild conditions (room temperature) to give triazoles with acyl or ester moieties in quantitative yields.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information (PDF)
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