Eosin Y Catalyzed Visible-Light-Driven Aerobic Oxidative Cyclization of Thioamides to 1,2,4-Thiadiazoles

Vishnu P. Srivastava; Arvind K. Yadav; Lal Dhar S. Yadav

doi:10.1055/s-0032-1318158

Synlett, Table of Contents

Synlett 2013; 24(4): 465-470
DOI: 10.1055/s-0032-1318158

letter

Eosin Y Catalyzed Visible-Light-Driven Aerobic Oxidative Cyclization of Thioamides to 1,2,4-Thiadiazoles

Vishnu P. Srivastava

Green Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad 211002, India Fax: +91(532)2460533 Email: ldsyadav@hotmail.com

,

Arvind K. Yadav

Green Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad 211002, India Fax: +91(532)2460533 Email: ldsyadav@hotmail.com

,

Lal Dhar S. Yadav*

Green Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad 211002, India Fax: +91(532)2460533 Email: ldsyadav@hotmail.com

› Author Affiliations

Abstract

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Abstract

A new approach for an efficient metal-free synthesis of 1,2,4-thiadiazoles from primary thioamides using visible light and air in the presence of eosin Y as a photoredox catalyst is reported. The protocol involves an aerobic oxidative cyclization of thioamides via the formation of C–N and C–S bonds to afford excellent yields of the products in a simple one-pot operation under mild conditions.

Key words

visible light - eosin Y - photoredox - thioamides - cyclization - thiadiazoles

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References

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