Synthesis, Table of Contents Synthesis 2013; 45(8): 1051-1059DOI: 10.1055/s-0032-1318476 paper © Georg Thieme Verlag Stuttgart · New York Efficient Transformation of Inactive Nitriles into 5-Substituted 1H-Tetrazoles Using Microwave Irradiation and Their Applications Hiroki Yoneyama a Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan Fax: +81(72)6901086 Email: harusawa@gly.oups.ac.jp , Yoshihide Usami a Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan Fax: +81(72)6901086 Email: harusawa@gly.oups.ac.jp , Seiji Komeda b Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie 513-8670, Japan , Shinya Harusawa* a Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan Fax: +81(72)6901086 Email: harusawa@gly.oups.ac.jp › Author Affiliations Recommend Article Abstract Buy Article All articles of this category Abstract Efficient transformations of inactive nitriles into 5-substituted 1H-tetrazoles in DMF in a microwave reactor are described. The present method is applied to the synthesis of tetrazolato-bridged dinuclear platinum(II) complex and tetrazole C1-ribonucleoside phosphoramidite. Key words Key wordstetrazole - DMF - microwave - platinum(II) complex - phosphoramidite Full Text References References For recent reviews on tetrazoles, see: 1a Bhatt U. Five-membered Heterocycles with Four Heteroatoms: Tetrazoles . In Modern Heterocyclic Chemistry . Vol. 3. Alvarez-Builla J, Vaquero JJ, Barluenga J. Wiley-VCH; Weinheim: 2011: 1401 1b Herr RJ. Bioorg. Med. Chem. 2002; 10: 3379 1c Bräse S, Gil C, Knepper K, Zimmermann V. Angew. Chem. Int. Ed. 2005; 44: 5188 1d Butler RN. Tetrazoles . In Comprehensive Heterocyclic Chemistry II . Vol. 4. Katritzky AR, Rees CW, Scriven EF. V. Pergamon; Oxford: 1996: 621 2 Finnegan WG, Henry RA, Lofquist R. J. Am. Chem. Soc. 1958; 80: 3908 3 Demko ZP, Sharpless KB. J. Org. Chem. 2001; 66: 7945 4a Alterman M, Hallberg A. J. Org. Chem. 2000; 65: 7984 4b Schmidt B, Meid D, Kieser D. 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