Toward Engineering a Biological Joint Replacement

Grace D. O'Connell; Eric G. Lima; Liming Bian; Nadeen O. Chahine; Michael B. Albro; James L. Cook; Gerard A. Ateshian; Clark T. Hung

doi:10.1055/s-0032-1319783

The Journal of Knee Surgery, Table of Contents

J Knee Surg 2012; 25(03): 187-196
DOI: 10.1055/s-0032-1319783

Special Focus Section

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Toward Engineering a Biological Joint Replacement

Grace D. O'Connell

¹Department of Biomedical Engineering, Columbia University, New York

,

Eric G. Lima

²Department of Mechanical Engineering, Cooper Union, New York

,

Liming Bian

³Department of Mechanical & Automation Engineering, Biomedical Engineering Programme, The Chinese University of Hong Kong, Hong Kong

,

Nadeen O. Chahine

⁴Department of Bioengineering, The Feinstein Institute for Medical Research, Manhasset, New York

,

Michael B. Albro

⁵Department of Mechanical Engineering, Columbia University, New York

,

James L. Cook

⁶Comparative Orthopaedic Laboratory, University of Missouri, Columbia, Missouri

,

Gerard A. Ateshian

⁵Department of Mechanical Engineering, Columbia University, New York

,

Clark T. Hung

¹Department of Biomedical Engineering, Columbia University, New York

› Author Affiliations

Abstract

Osteoarthritis is a major cause of disability and pain for patients in the United States. Treatments for this degenerative disease represent a significant challenge considering the poor regenerative capacity of adult articular cartilage. Tissue-engineering techniques have advanced over the last two decades such that cartilage-like tissue can be cultivated in the laboratory for implantation. Even so, major challenges remain for creating fully functional tissue. This review article overviews some of these challenges, including overcoming limitations in nutrient supply to cartilage, improving in vitro collagen production, improving integration of engineered cartilage with native tissue, and exploring the potential for engineering full articular surface replacements.

Keywords

biological joint replacement - cartilage - tissue-engineering - nutrient diffusion - collagen production

Full Text

References

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