Ursolic acid (UA) was known for its pharmacological effects, such as anti-tumor, anti-inflammatory and antimicrobial activities. In BALB/c mice, we found that UA-treated groups had been suppressed eosinophil infiltration, allergic airway inflammation and AHR. Our data suggest that the therapeutic mechanism by which UA effectively treats asthma is based on reductions of Th2 cytokines (IL-5, IL-13), OVA-specific IgE production and eosinophil infiltration through Th2-STAT6 pathway and IL-17-NF-κB pathway.
