Toxicity of the ethanol extract from Antidesma acidum Retz

U Nanna; S Sireeratawong; S Thamaree; K Ingkaninan; K Jaijoy

doi:10.1055/s-0032-1320819

Planta Medica, Inhaltsverzeichnis

Toxicity of the ethanol extract from Antidesma acidum Retz

U Nanna ¹, S Sireeratawong ¹, S Thamaree ², K Ingkaninan ³, K Jaijoy ⁴

¹Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand
²Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
³Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.
⁴Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand

Abstract

Toxicity tests of 95% ethanol extract of the root from Antidesma acidum were studied in male and female rats. The oral acute toxicity test at 5,000mg/kg revealed that the ethanol extract did not produce toxic effects on signs, general behavious, mortality and groß appearance of internal organs of rats. Furthermore, the oral subacute toxicity test at the dose of 1,000mg/kg/day displayed no significant changes in body and internal organs weights, normal hematological and clinical blood chemistry values. Histological examination also showed normal architecture of all internal organs. In conclusion, A. acidum extract did not produce any toxicity in oral acute and subacute toxicity studies.