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Semin Liver Dis 2012; 32(03): 195-200
DOI: 10.1055/s-0032-1323623
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Virology of Hepatitis D Virus

John M. Taylor
1   Fox Chase Cancer Center, Philadelphia, Pennsylvania
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Publication History

Publication Date:
29 August 2012 (online)

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Abstract

Although much of the current understanding of the replication of hepatitis D virus (HDV) has been gained from ex vivo rather than in vivo studies, many seemingly unique aspects have been discovered. These include the ultra-small size and circular conformation of the RNA genome, the presence on the viral RNAs of two ribozymes, the role of RNA-directed RNA transcription by redirection of host enzymes, the requirement of site-specific, posttranscriptional RNA-editing, and more. This review addresses recent insights, remaining controversies, and just plain deficits in our understanding of HDV replication.

Keywords

circular RNA - RNA-directed RNA transcription - RNA editing - ribozymes - posttranslational modifications
 

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