Das „feedback loop model“ – ein neues hypothetisches Modell zur frühen Karzinogenese

The classical somatic mutation theory of carcinogenesis and metastases (SMT) explains malignant transformation by incidence of mutations in oncogenes or tumor suppressor genes. These mutations lead to a cell-autonomous activation and thereby growth advantage compared to neighbouring cells. However, this SMT does not seem fit to completely explain many characteristics of carcinomas. Contrary to the cell centered view on carcinogenesis of the SMT, research recently showed more and more evidence that the tumor microenvironment is involved in carcinogenesis, too.

We want to present a new model on carcinogenesis that considers the important contribution of the tumor microenvironment in carcinogenesis and complements the classical SMT. The „feedback” model emphasizes the role of an altered spatiotemporal communication between epithelial and stromal cells in carcinogenesis. In this model, a dysfunctional intracellular signaling processing of epithelial cells leads to an inadequate cellular response to stimuli from associated stromal or inflammatory cells. By this anomalous answer, a „feedback loop” of the information flow between parenchymal and stromal cells is created. This might cause a perpetuation of the activated state of cells and the tumor micromilieu, which can be compared to a resonance disaster.

Klinische und experimentelle Forschung
Freitag, 21. September 2012/17:30–19:00/Saal 13_14