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Am J Perinatol 2013; 30(05): 353-358
DOI: 10.1055/s-0032-1324701
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Prognostic Factors of Mortality in Very Low-Birth-Weight Infants with Neonatal Sepsis of Nosocomial Origin

Carlos Lobete Prieto
1   Service of Neonatology, Hospital Universitario Central de Asturias, Asturias, Spain
,
Belén Fernández Colomer
1   Service of Neonatology, Hospital Universitario Central de Asturias, Asturias, Spain
,
José Blas López Sastre
1   Service of Neonatology, Hospital Universitario Central de Asturias, Asturias, Spain
› Author Affiliations
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Publication History

06 February 2012

15 May 2012

Publication Date:
14 August 2012 (online)

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Abstract

Objective To identify the variables associated with sepsis-associated mortality, as well as to develop a severity risk score to predict death in very low-birth-weight (VLBW) neonates affected by nosocomial sepsis.

Study Design Retrospective cohort study. Infants weighing ≤1500 g with neonatal sepsis of nosocomial origin were included. Epidemiological, clinical, and laboratory variables were recorded at onset (0 hours), at 12 hours, and at 24 hours. Bivariate and multivariate analyses were performed.

Result The study population included 95 VLBW infants who presented 129 episodes of nosocomial sepsis. In the bivariate analysis, gram-negative bacilli as the etiology of sepsis, seizures, age, postconceptional age, weight, serum procalcitonin (24 hours), platelet count (24 hours), blood urea nitrogen (0 and 24 hours), creatinine (24 hours), diuresis (12 and 24 hours), mean blood pressure (12 and 24 hours), pH, base excess (0, 12, and 24 hours), and SpO2 (pulse oximetric saturation):Fio 2 (fraction of inspired oxygen) ratio (12 and 24 hours) were significantly associated with mortality. In the multivariate analysis, weight at the onset of sepsis, base excess (0 hours), and SpO2:Fio 2 ratio (12 hours) were independent predictors of mortality.

Conclusion A lower weight at the onset of sepsis, base excess, and SpO2:Fio 2 ratio are useful to predict nosocomial sepsis-associated mortality in VLBW infants.

Keywords

blood - infection - microbiology - mortality - infant - low birth weight
 

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