Am J Perinatol 2013; 30(05): 343-346
DOI: 10.1055/s-0032-1324707
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Fetal Links to Chronic Disease: The Role of Gestational Diabetes Mellitus

Celeste Durnwald
1   Department of Obstetrics and Gynecology, The University of Pennsylvania, Pennsylvania
,
Mark Landon
2   Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio
› Institutsangaben
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Publikationsverlauf

09. April 2012

09. Mai 2012

Publikationsdatum:
14. August 2012 (online)

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Abstract

A growing body of literature suggests that chronic disease has much of its origins in the fetal response to the intrauterine environment, a concept known as “fetal programming.” Longitudinal studies have demonstrated that higher rates of obesity, impaired glucose tolerance, hypertension, and dyslipidemia are evident in the offspring of diabetic women. This review focuses on the implications of intrauterine exposure to an altered maternal metabolic milieu and the risk of childhood obesity and metabolic dysfunction.