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Zahnmedizin up2date 2013; 7(4): 357-378
DOI: 10.1055/s-0032-1325025
Oralchirurgie
Georg Thieme Verlag KG Stuttgart · New York

Zahnärztliche Betreuung von Tumorpatienten

Jens C. Eberle
,
Knut A. Grötz
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Publication History

Publication Date:
14 August 2013 (online)

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Einleitung

Für die Therapiebegleitung von Patienten mit Tumorerkrankungen im Kopf-Hals-Bereich sowie den Folgen tumortherapeutischer Kopf-Hals-Bestrahlung, aber auch Tumorpatienten mit medikamenteninduzierten Folgen für die Mundhöhle kommt der zahnärztlichen Praxis heute eine entscheidende Rolle zu.

 

  • Literatur

  • 1 Bernier J, Vermorken JB, Koch WM. Adjuvant therapy in patients with resected poor-risk head and neck cancer. J Clin Oncol 2006; 24 (17) 2629-2635
    CrossrefSearch in Google Scholar
  • 2 Rodgers jr. LW et al. Management of squamous cell carcinoma of the floor of mouth. Head Neck 1993; 15 (1) 16-19
    CrossrefSearch in Google Scholar
  • 3 Jham BC et al. Oral health status of 207 head and neck cancer patients before, during and after radiotherapy. Clin Oral Investig 2008; 12 (1) 19-24
    CrossrefSearch in Google Scholar
  • 4 Grötz KA. Prophylaxe und Therapie der Folgen therapeutischer Tumor-Bestrahlung im Mund-Kiefer-Gesichtsbereich. Berlin: Quintessenz; 2001
    CrossrefSearch in Google Scholar
  • 5 Grötz KA. Dental care for patients with antineoplastic radiotherapy of the head and neck. Strahlenther Onkol 2003; 179 (4) 275-278
    Search in Google Scholar
  • 6 Hartmann JT et al. Leitlinienempfehlungen des Arbeitskreises Supportive Maßnahmen in der Onkologie (ASO) der Deutschen Krebsgesellschaft: Schleimhauttoxizität. Im Focus Onkologie 2008; 3: 51-53
    Search in Google Scholar
  • 7 De Moor RJ et al. Two-year clinical performance of glass ionomer and resin composite restorations in xerostomic head- and neck-irradiated cancer patients. Clin Oral Investig 2009; 15: 31-38
    Search in Google Scholar
  • 8 Bulucu B et al. Effect of radiotherapy on the microleakage of adhesive systems. J Adhes Dent 2009; 11 (4) 305-309
    Search in Google Scholar
  • 9 Curi MM, Dib LL. Osteoradionecrosis of the jaws: a retrospective study of the background factors and treatment in 104 cases. J Oral Maxillofac Surg 1997; 55 (6) 540-544 discussion 545–546
    CrossrefPubMedSearch in Google Scholar
  • 10 Koga DH, Salvajoli JV, Alves FA. Dental extractions and radiotherapy in head and neck oncology: review of the literature. Oral Dis 2008; 14 (1) 40-44
    CrossrefPubMedSearch in Google Scholar
  • 11 Studer G et al. Risk-adapted dental care prior to intensity-modulated radiotherapy (IMRT). Schweiz Monatsschr Zahnmed 2011; 121 (3) 216-229
    Search in Google Scholar
  • 12 Nabil S, Samman N. Incidence and prevention of osteoradionecrosis after dental extraction in irradiated patients: a systematic review. Int J Oral Maxillofac Surg 2011; 40 (3) 229-243
    CrossrefPubMedSearch in Google Scholar
  • 13 Bonan PR et al. Dental management of low socioeconomic level patients before radiotherapy of the head and neck with special emphasis on the prevention of osteoradionecrosis. Braz Dent J 2006; 17 (4) 336-342
    CrossrefSearch in Google Scholar
  • 14 Ben-David MA et al. Lack of osteoradionecrosis of the mandible after intensity-modulated radiotherapy for head and neck cancer: likely contributions of both dental care and improved dose distributions. Int J Radiat Oncol Biol Phys 2007; 68 (2) 396-402
    CrossrefSearch in Google Scholar
  • 15 Katsura K et al. Relationship between oral health status and development of osteoradionecrosis of the mandible: a retrospective longitudinal study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 105 (6) 731-738
    Search in Google Scholar
  • 16 Pyykonen H et al. Late effects of radiation treatment of tongue and floor-of-mouth cancer on the dentition, saliva secretion, mucous membranes and the lower jaw. Int J Oral Maxillofac Surg 1986; 15 (4) 401-409
    CrossrefSearch in Google Scholar
  • 17 Dörr W et al. Therapeutische Beeinflussung der radiogenen oralen Mukositis. Strahlenther Onkol 1997; 173: 183-192
    CrossrefSearch in Google Scholar
  • 18 Campbell I, Illingworth M. Can patients wash during radiotherapy to the breast or chest wall? A randomized controlled trial. Clin Oncol 1992; 4: 78-82
    CrossrefSearch in Google Scholar
  • 19 Wada A et al. Radiation-induced xerostomia: objective evaluation of salivary gland injury using MR sialography. AJNR Am J Neuroradiol 2009; 30 (1) 53-58
    CrossrefSearch in Google Scholar
  • 20 Dijkema T et al. Parotid gland function after radiotherapy: the combined michigan and utrecht experience. Int J Radiat Oncol Biol Phys 2010; 78 (2) 449-453
    CrossrefSearch in Google Scholar
  • 21 Murdoch-Kinch CA et al. Dose-effect relationships for the submandibular salivary glands and implications for their sparing by intensity modulated radiotherapy. Int J Radiat Oncol Biol Phys 2008; 72 (2) 373-382
    CrossrefSearch in Google Scholar
  • 22 Jensen SB et al. A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact. Support Care Cancer 2010; 18 (8) 1061-1079
    CrossrefSearch in Google Scholar
  • 23 Groetz KA, Schmidt BLJ. ONKO II: Ambulante TU-Betreuung. In: Groetz KA, Schmidt-Westhausen AM, Wagner W, Hrsg. Handbuch MKG UPDATE. Berlin: med publico GmbH; 2012
    Search in Google Scholar
  • 24 Ma C et al. Does amifostine have radioprotective effects on salivary glands in high-dose radioactive iodine-treated differentiated thyroid cancer. Eur J Nucl Med Mol Imaging 2010; 37 (9) 1778-1785
    CrossrefSearch in Google Scholar
  • 25 Grotz KA, Duschner H, Wagner W. Confocal laser scanning microscopy (CLSM): histotomography of altered dental hard tissue in pathological mouth cavity ecology. Mund Kiefer Gesichtschir 1997; 1 (1) 39-43
    CrossrefSearch in Google Scholar
  • 26 Silva AR et al. Patterns of demineralization and dentin reactions in radiation-related caries. Caries Res 2009; 43 (1) 43-49
    CrossrefSearch in Google Scholar
  • 27 Silva AR et al. Radiation-related caries and early restoration failure in head and neck cancer patients. A polarized light microscopy and scanning electron microscopy study. Support Care Cancer 2009; 18: 83-87
    Search in Google Scholar
  • 28 Jansma J et al. In vivo study on the prevention of postradiation caries. Caries Res 1989; 23 (3) 172-178
    CrossrefSearch in Google Scholar
  • 29 Chambers MS et al. Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 2: Phase I study. Oral Oncol 2006; 42 (9) 946-953
    CrossrefSearch in Google Scholar
  • 30 Aitasalo K et al. A modified protocol for early treatment of osteomyelitis and osteoradionecrosis of the mandible. Head Neck 1998; 20 (5) 411-417
    CrossrefSearch in Google Scholar
  • 31 Groetz KA, Schmidt BLJ. ONKO I: Ambulante TU-Betreuung. In: Groetz KA, Schmidt-Westhausen AM, Hrsg. Handbuch MKG UPDATE. Berlin: med publico GmbH; 2010
    Search in Google Scholar
  • 32 Infante-Cossio P et al. Impact of treatment on quality of life for oral and oropharyngeal carcinoma. Int J Oral Maxillofac Surg 2009; 38 (10) 1052-1058
    CrossrefSearch in Google Scholar
  • 33 OʼFearraigh P. Review of methods used in the reconstruction and rehabilitation of the maxillofacial region. J Ir Dent Assoc 2010; 56 (1) 32-37
    Search in Google Scholar
  • 34 Grötz KA, Wagner W. S3-Leitlinie: Implantat-Versorgung zur oralen Rehabilitation im Zusammenhang mit Kopf-Hals-Bestrahlung, Leitlinie der Deutschen Gesellschaft für Mund-, Kiefer- und Gesichtschirurgie, Stand 12/2007. DGMKG; AWMF online 2007
    Search in Google Scholar
  • 35 Wagner W, Kuffner HD, Hartmann U. Der bestrahlte Patient als Risikopatient bei zahnärztlich-chirurgischen Eingriffen. Deutsche Zahnärztliche Zeitschrift 1986; 41: 440-443
    Search in Google Scholar
  • 36 Fritz GW et al. Efficacy of pre- and postirradiation hyperbaric oxygen therapy in the prevention of postextraction osteoradionecrosis: a systematic review. J Oral Maxillofac Surg 2010; 68 (11) 2653-2660
    CrossrefPubMedSearch in Google Scholar
  • 37 Suarez-Cunqueiro MM et al. Speech and swallowing impairment after treatment for oral and oropharyngeal cancer. Arch Otolaryngol Head Neck Surg 2008; 134 (12) 1299-1304
    CrossrefSearch in Google Scholar
  • 38 Rogers SN, Johnson IA, Lowe D. Xerostomia after treatment for oral and oropharyngeal cancer using the University of Washington saliva domain and a xerostomia-related quality-of-life scale. Int J Radiat Oncol Biol Phys 2010; 77: 16-23
    CrossrefPubMedSearch in Google Scholar
  • 39 Dirix P et al. The influence of xerostomia after radiotherapy on quality of life: results of a questionnaire in head and neck cancer. Support Care Cancer 2008; 16 (2) 171-179
    CrossrefSearch in Google Scholar
  • 40 Ho KF et al. Developing a CTCAEs patient questionnaire for late toxicity after head and neck radiotherapy. Eur J Cancer 2009; 45 (11) 1992-1998
    CrossrefSearch in Google Scholar
  • 41 Langendijk JA et al. Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy. J Clin Oncol 2008; 26 (22) 3770-3776
    CrossrefSearch in Google Scholar
  • 42 Chaukar DA et al. Quality of life in head and neck cancer survivors: a cross-sectional survey. Am J Otolaryngol 2009; 30 (3) 176-180
    CrossrefSearch in Google Scholar
  • 43 Momm F et al. Xerostomia. Improved care using a spray with herbal polysaccharides. HNO 2010; 58 (7) 680-685
    CrossrefSearch in Google Scholar
  • 44 Pfister DG et al. Acupuncture for pain and dysfunction after neck dissection: results of a randomized controlled trial. J Clin Oncol 2010; 28 (15) 2565-2570
    CrossrefSearch in Google Scholar
  • 45 Kielbassa A, Shohadai S, Schulte-Monting J. Effect of saliva substitutes on mineral content of demineralized and sound dental enamel. Supp Care Cancer 2000; 9: 40-47
    Search in Google Scholar
  • 46 Kielbassa A, Meyer-Lueckel H. Die Auswirkungen von Speichelersatzmitteln und Mundspüllösungen auf Dentin. Schweiz Monatsschr Zahnmed 2001; 111: 1060-1066
    Search in Google Scholar
  • 47 Baum BJ et al. Aquaporin-1 gene transfer to correct radiation-induced salivary hypofunction. Handb Exp Pharmacol 2009; 190: 403-418
    Search in Google Scholar
  • 48 Baum BJ et al. Development of a gene transfer-based treatment for radiation-induced salivary hypofunction. Oral Oncol 2010; 46 (1) 4-8
    CrossrefSearch in Google Scholar
  • 49 Grundmann O et al. Restoration of radiation therapy-induced salivary gland dysfunction in mice by post therapy IGF-1 administration. BMC Cancer 2010; 10: 417
    CrossrefPubMedSearch in Google Scholar
  • 50 Rotter N et al. Salivary gland stem cells : Can they restore radiation-induced salivary gland dysfunction?. HNO 2010; 58 (6) 556-563
    CrossrefSearch in Google Scholar
  • 51 Jacobson AS et al. Paradigm shifts in the management of osteoradionecrosis of the mandible. Oral Oncol 2010; 46 (11) 795-801
    CrossrefPubMedSearch in Google Scholar
  • 52 Suh JD et al. Disease relapse after segmental resection and free flap reconstruction for mandibular osteoradionecrosis. Otolaryngol Head Neck Surg 2010; 142 (4) 586-591
    CrossrefPubMedSearch in Google Scholar
  • 53 Pautke C et al. Tetracycline bone fluorescence: a valuable marker for osteonecrosis characterization and therapy. J Oral Maxillofac Surg 2010; 68 (1) 125-129
    CrossrefSearch in Google Scholar
  • 54 Delanian S et al. Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial. Int J Radiat Oncol Biol Phys 2011; 80: 832-839
    CrossrefPubMedSearch in Google Scholar
  • 55 Rosen LS et al. Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with nonsmall cell lung carcinoma and other solid tumors: a randomized, Phase III, double-blind, placebo-controlled trial. Cancer 2004; 100 (12) 2613-21
    CrossrefSearch in Google Scholar
  • 56 Saad F et al. Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancer. J Natl Cancer Inst 2004; 96 (11) 879-882
    CrossrefSearch in Google Scholar
  • 57 Carter GD, Goss AN. Bisphosphonates and avascular necrosis of the jaws. Aust Dent J 2003; 48 (4) 268
    Search in Google Scholar
  • 58 Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of jaws: a growing epidemic. J Oral Maxillofac Surg 2003; 61 (9) 1115-1117
    CrossrefPubMedSearch in Google Scholar
  • 59 Migliorati CA. Bisphosphanates and oral cavity avascular bone necrosis. J Clin Oncol 2003; 21 (22) 4253-4254
    CrossrefSearch in Google Scholar
  • 60 Groetz KA, Piesold JU, Al-Nawas B. S3-Leitlinie: Bisphosphonat-assoziierte Kiefernekrose (BP-ONJ) und andere Medikamenten-assoziierte Kiefernekrosen. AWMF 007-091,. http://www.awmf.org/uploads/tx_szleitlinien/007-091l_S3_Bisphosphonat-assoziierte_Kiefernekrose_2012-04.pdf Stand: 04/2012
  • 61 Lo JC et al. Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure. J Oral Maxillofac Surg 2010; 68 (2) 243-253
    CrossrefSearch in Google Scholar
  • 62 Yamazaki T et al. Risk of osteomyelitis of the jaw induced by oral bisphosphonates in patients taking medications for osteoporosis: a hospital-based cohort study in Japan. Bone 2012; 51 (5) 882-887
    CrossrefSearch in Google Scholar
  • 63 Hines SL et al. Immediate versus delayed zoledronic acid for prevention of bone loss in postmenopausal women with breast cancer starting letrozole after tamoxifen-N03CC. Breast Cancer Res Treat 2009; 117 (3) 603-609
    CrossrefSearch in Google Scholar
  • 64 Smith MR et al. Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: results of a phase 3, randomised, placebo-controlled trial. Lancet 2012; 379 (9810) 39-46
    CrossrefSearch in Google Scholar
  • 65 Walter C et al. Prevalence of bisphosphonate associated osteonecrosis of the jaws in multiple myeloma patients. Head Face Med 2010; 6 (1) 11
    CrossrefSearch in Google Scholar
  • 66 Bonomi M et al. Renal toxicity and osteonecrosis of the jaw in cancer patients treated with bisphosphonates: a long-term retrospective analysis. Med Oncol 2010; 27 (2) 224-229
    CrossrefSearch in Google Scholar
  • 67 Vahtsevanos K et al. Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw. J Clin Oncol 2009; 27 (32) 5356-5362
    CrossrefSearch in Google Scholar
  • 68 Ruggiero SL et al. Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg 2004; 62 (5) 527-534
    CrossrefPubMedSearch in Google Scholar
  • 69 Ruggiero SL et al. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws-2009 update. J Oral Maxillofac Surg 2009; 67(5 Suppl): 2-12
    CrossrefPubMedSearch in Google Scholar
  • 70 Otto S, Hafner S, Grotz KA. The role of inferior alveolar nerve involvement in bisphosphonate-related osteonecrosis of the jaw. J Oral Maxillofac Surg 2009; 67 (3) 589-592
    CrossrefSearch in Google Scholar
  • 71 Groetz KA, Schmidt BLJ. Bisphosphonat-assoziierte Kiefernekrose. In: Groetz KA, Schmidt-Westhausen AM, Hrsg. Handbuch MKG UPDATE. Berlin: med publico GmbH; 2010
    Search in Google Scholar
  • 72 Vandone AM et al. Impact of dental care in the prevention of bisphosphonate-associated osteonecrosis of the jaw: a single-center clinical experience. Ann Oncol 2012; 23: 193-200
    CrossrefSearch in Google Scholar
  • 73 Haidar A et al. Bisphosphonate (zoledronic acid)-induced osteonecrosis of the jaw. Scand J Urol Nephrol 2009; 43 (6) 442-444
    CrossrefSearch in Google Scholar
  • 74 Montefusco V et al. Antibiotic prophylaxis before dental procedures may reduce the incidence of osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates. Leuk Lymphoma 2008; 49 (11) 2156-2162
    CrossrefSearch in Google Scholar
  • 75 Schubert M et al. The saxon bisphosphonate register – therapy and prevention of bisphosphonate-related osteonecrosis of the jaws. Oral Oncol 2012; 48 (4) 349-354
    CrossrefSearch in Google Scholar
  • 76 Carini F et al. Surgical protocol in patients at risk for bisphosphonate osteonecrosis of the jaws: clinical use of serum telopetide CTX in preventive monitoring of surgical risk. Ann Stomatol (Roma) 2012; 3 (1) 31-36
    Search in Google Scholar
  • 77 Kassolis JD et al. Histopathologic findings in bone from edentulous alveolar ridges: a role in osteonecrosis of the jaws?. Bone 2010; 47 (1) 127-130
    CrossrefSearch in Google Scholar
  • 78 Saia G et al. Occurrence of bisphosphonate-related osteonecrosis of the jaw after surgical tooth extraction. J Oral Maxillofac Surg 2010; 68 (4) 797-804
    CrossrefSearch in Google Scholar
  • 79 Treister N et al. Dental panoramic radiographic evaluation in bisphosphonate-associated osteonecrosis of the jaws. Oral Dis 2009; 15 (1) 88-92
    CrossrefSearch in Google Scholar
  • 80 Bisdas S et al. Biphosphonate-induced osteonecrosis of the jaws: CT and MRI spectrum of findings in 32 patients. Clin Radiol 2008; 63 (1) 71-77
    CrossrefSearch in Google Scholar
  • 81 Stockmann P et al. Panoramic radiograph, computed tomography or magnetic resonance imaging. Which imaging technique should be preferred in bisphosphonate-associated osteonecrosis of the jaw? A prospective clinical study. Clin Oral Investig 2010; 14: 311-317
    CrossrefSearch in Google Scholar
  • 82 Barragan-Adjemian C et al. Bisphosphonate-related osteonecrosis of the jaw: model and diagnosis with cone beam computerized tomography. Cells Tissues Organs 2009; 189: 284-288
    CrossrefSearch in Google Scholar
  • 83 OʼRyan FS et al. Intravenous bisphosphonate-related osteonecrosis of the jaw: bone scintigraphy as an early indicator. J Oral Maxillofac Surg 2009; 67 (7) 1363-1372
    CrossrefSearch in Google Scholar
  • 84 Mücke T et al. Outcome of treatment and parameters influencing recurrence in patients with bisphosphonate-related osteonecrosis of the jaws. J Cancer Res Clin Oncol 2011; 137 (5) 907-913
    CrossrefSearch in Google Scholar
  • 85 Andriani A et al. Evolution of bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma and Waldenstromʼs macroglobulinemia: a retrospective multicentric study. Blood Cancer J 2012; 2 (3) e62
    CrossrefSearch in Google Scholar
  • 86 Lazarovici TS et al. Bisphosphonate-related osteonecrosis of the jaws: a single-center study of 101 patients. J Oral Maxillofac Surg 2009; 67 (4) 850-855
    CrossrefSearch in Google Scholar
  • 87 Stockmann P et al. Osteotomy and primary wound closure in bisphosphonate-associated osteonecrosis of the jaw: a prospective clinical study with 12 months follow-up. Support Care Cancer 2010; 18: 449-460
    CrossrefSearch in Google Scholar
  • 88 Wilde F et al. The role of surgical therapy in the management of intravenous bisphosphonates-related osteonecrosis of the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 111: 153-163
    Search in Google Scholar
  • 89 Vescovi P et al. Surgical approach with Er:YAG laser on osteonecrosis of the jaws (ONJ) in patients under bisphosphonate therapy (BPT). Lasers Med Sci 2010; 25: 101-113
    CrossrefSearch in Google Scholar
  • 90 Treister NS, Friedland B, Woo SB. Use of cone-beam computerized tomography for evaluation of bisphosphonate-associated osteonecrosis of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109 (5) 753-764
    Search in Google Scholar
  • 91 Hoefert S, Eufinger H. Relevance of a prolonged preoperative antibiotic regime in the treatment of bisphosphonate-related osteonecrosis of the jaw. J Oral Maxillofac Surg 2011; 69 (2) 362-380
    CrossrefSearch in Google Scholar
  • 92 Lemound J et al. Bisphosphonate-associated osteonecrosis of the mandible: reliable soft tissue reconstruction using a local myofascial flap. Clin Oral Investig 2012; 16: 1143-1152
    CrossrefPubMedSearch in Google Scholar
  • 93 Gallego L et al. The use of pedicled buccal fat pad combined with sequestrectomy in bisphosphonate-related osteonecrosis of the maxilla. Med Oral Patol Oral Cir Bucal 2012; 17 (2) e236-e241
    Search in Google Scholar
  • 94 Curi MM et al. Bisphosphonate-related osteonecrosis of the jaws-an initial case series report of treatment combining partial bone resection and autologous platelet-rich plasma. J Oral Maxillofac Surg 2011; 69 (9) 2465-2472
    CrossrefSearch in Google Scholar
  • 95 Henry D et al. A double-blind, randomized study of denosumab versus zoledronic acid for the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma. in ECCO 15 – 34th ESMO Multidisciplinary Congress, 20 – 24 September 2009. 2009, Abstract 20LBA and oral presentation: Berlin, Germany
  • 96 Stopeck AT et al. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. J Clin Oncol 2010; 28: 5132-5139
    CrossrefSearch in Google Scholar
  • 97 Fizazi K, Carducci M, Smith M. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with castration resistant prostate cancer. JCO 2010; (Suppl. 28) abstract LBA 4507, ASCO, 2010
    Search in Google Scholar
  • 98 Guarneri V et al. Bevacizumab and osteonecrosis of the jaw: incidence and association with bisphosphonate therapy in three large prospective trials in advanced breast cancer. Breast Cancer Res Treat 2010; 122 (1) 181-188
    CrossrefSearch in Google Scholar
  • 99 Christodoulou C et al. Combination of bisphosphonates and antiangiogenic factors induces osteonecrosis of the jaw more frequently than bisphosphonates alone. Oncology 2009; 76 (3) 209-211
    CrossrefSearch in Google Scholar
  • 100 Grötz KA et al. Bei welchen Bisphoshonat-Patienten darf ich eigentlich implantieren? Ein systematisches Review. [In which bisphosphonate patients am I allowed to place implants? A systematic review.] ZZI Zeitschrift für Zahnärztliche Implantologie 2010; 26 (2) 153-161
    Search in Google Scholar
  • 101 Migliorati CA, Mattos K, Palazzolo MJ. How patients lack of knowledge about oral bisphosphonates can interfere with medical and dental care. J Am Dent Assoc 2010; 141 (5) 562-566
    CrossrefSearch in Google Scholar
  • 102 Lopez-Jornet P et al. Bisphosphonate-associated osteonecrosis of the jaw. Knowledge and attitudes of dentists and dental students: a preliminary study. J Eval Clin Pract 2010; 16 (5) 878-882
    CrossrefPubMedSearch in Google Scholar