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Krankenhaushygiene up2date 2013; 08(01): 49-63
DOI: 10.1055/s-0032-1326244
Nosokomiale Infektionen
© Georg Thieme Verlag KG Stuttgart · New York

ESBL- und AmpC-produzierende Enterobakterien bei Tieren

Anika Friese
,
Uwe Rösler
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Publication Date:
27 March 2013 (online)

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Kernaussagen

ESBL- und AmpC-bildende Enterobakterien, speziell E. coli, sind bisher v. a. als Verursacher von Infektionen bei Mensch und Tier bekannt. Aktuelle Studien zeigen jedoch auch eine Kolonisierung dieser Keime bei gesunden Heim-, Nutz- und Wildtieren sowie ein Vorkommen in bzw. auf Lebensmitteln. Eine Übertragung der ESBL- und AmpC-bildenden Enterobakterien zwischen Mensch, Tier und Umwelt scheint wahrscheinlich, wobei noch keine Aussagen über die Richtung des Transfers oder eine Einschätzung der Risiken gemacht werden kann. Aktuelle Untersuchungen unterstreichen jedoch eine Verwandtschaft der resistenten Mikroorganismen, da gleiche Sequenztypen sowie gleiche Enzymvarianten bei aus Menschen, Tieren und auch aus Lebensmitteln isolierten Keimen gefunden wurden. Eine große Gefahr ausgehend von der Besiedlung mit den resistenten Keimen besteht höchstwahrscheinlich in der Übertragung der ESBL-/AmpC-kodierenden Plasmide auf pathogene Mikroorganismen und eine somit zunehmend schwierigere antimikrobielle Therapie von Infektionen.

Eine Senkung des Vorkommens von multiresistenten Erregern in Tierhaltungen wird angestrebt, wofür derzeit verschiedene Konzepte entwickelt werden. Dabei stehen ein transparentes und intensives Monitoring von gesunden Tierbeständen, die zentrale Erfassung aller Arzneimittelanwendungen in Tierhaltungen, eine Verbesserung der Haltungs- und Hygienebedingungen sowie ein verantwortungsbewusster Einsatz von Antibiotika nach existierenden Leitlinien in Veterinär- und Humanmedizin im Vordergrund.

 

  • Literatur

  • 1 Medeiros AA. Evolution and dissemination of beta-lactamases accelerated by generations of beta-lactam antibiotics. Clin Infect Dis 1997; 24 Suppl 1: S 19-45
    CrossrefSearch in Google Scholar
  • 2 Livermore DM. Defining an extended-spectrum beta-lactamase. Clin Microbiol Infect 2008; 14: 3-10
    Search in Google Scholar
  • 3 Fischer J, Rodriguez I, Schmoger S et al. Salmonella enterica subsp. enterica producing VIM-1 carbapenemase isolated from livestock farms. J Antimicrob Chemother 2013; 68: 478-480
    CrossrefSearch in Google Scholar
  • 4 Fischer J, Rodriguez I, Schmoger S et al. Escherichia coli producing VIM-1 carbapenemase isolated on a pig farm. J Antimicrob Chemother 2012; 67: 1793-1795
    CrossrefSearch in Google Scholar
  • 5 Teshager T, Dominguez L, Moreno MA et al. Isolation of an SHV-12 beta-lactamase-producing Escherichia coli strain from a dog with recurrent urinary tract infections. Antimicrob Agents Chemother 2000; 44: 3483-3484
    CrossrefSearch in Google Scholar
  • 6 Ewers C, Grobbel M, Bethe A et al. Extended-spectrum beta-lactamases-producing gram-negative bacteria in companion animals: action is clearly warranted!. Berl Munch Tierarztl Wochenschr 2011; 124: 94-101
    Search in Google Scholar
  • 7 Ewers C, Bethe A, Semmler T et al. Extended-spectrum beta-lactamase-producing and AmpC-producing Escherichia coli from livestock and companion animals, and their putative impact on public health: a global perspective. Clin Microbiol Infect 2012; 18: 646
    CrossrefSearch in Google Scholar
  • 8 Timofte D, Dandrieux J, Wattret A et al. Detection of extended-spectrum-beta-lactamase-positive Escherichia coli in bile isolates from two dogs with bacterial cholangiohepatitis. J Clin Microbiol 2011; 49: 3411-3414
    CrossrefSearch in Google Scholar
  • 9 Schink AK, Kadlec K, Schwarz S. Analysis of bla(CTX-M)-carrying plasmids from Escherichia coli isolates collected in the BfT-GermVet study. Appl Environ Microbiol 2011; 77: 7142-7146
    CrossrefSearch in Google Scholar
  • 10 Sidjabat HE, Hanson ND, Smith-Moland E et al. Identification of plasmid-mediated extended-spectrum and AmpC beta-lactamases in Enterobacter spp. isolated from dogs. J Med Microbiol 2007; 56: 426-434
    CrossrefSearch in Google Scholar
  • 11 O'Keefe A, Hutton TA, Schifferli DM et al. First detection of CTX-M and SHV extended-spectrum beta-lactamases in Escherichia coli urinary tract isolates from dogs and cats in the United States. Antimicrob Agents Chemother 2010; 54: 3489-3492
    CrossrefSearch in Google Scholar
  • 12 Costa D, Poeta P, Brinas L et al. Detection of CTX-M-1 and TEM-52 beta-lactamases in Escherichia coli strains from healthy pets in Portugal. J Antimicrob Chemother 2004; 54: 960-961
    Search in Google Scholar
  • 13 Sallem RB, Gharsa H, Slama KB et al. First detection of CTX-M-1, CMY-2, and QnrB19 resistance mechanisms in fecal Escherichia coli isolates from healthy pets in Tunisia. Vector Borne Zoonotic Dis 2013;
    Search in Google Scholar
  • 14 Johns I, Verheyen K, Good L et al. Antimicrobial resistance in faecal Escherichia coli isolates from horses treated with antimicrobials: a longitudinal study in hospitalised and non-hospitalised horses. Vet Microbiol 2012; 159: 381-389
    CrossrefSearch in Google Scholar
  • 15 Guenther S, Ewers C, Wieler LH. Extended-spectrum beta-lactamases producing E. coli in wildlife, yet another form of environmental pollution?. Front Microbiol 2011; 2: 246
    Search in Google Scholar
  • 16 Allen HK, Donato J, Wang HH et al. Call of the wild: antibiotic resistance genes in natural environments. Nat Rev Microbiol 2010; 8: 251-259
    CrossrefSearch in Google Scholar
  • 17 Brinas L, Moreno MA, Zarazaga M et al. Detection of CMY-2, CTX-M-14, and SHV-12 beta-lactamases in Escherichia coli fecal-sample isolates from healthy chickens. Antimicrob Agents Chemother 2003; 47: 2056-2058
    CrossrefSearch in Google Scholar
  • 18 Bortolaia V, Guardabassi L, Trevisani M et al. High diversity of extended-spectrum beta-lactamases in Escherichia coli isolates from Italian broiler flocks. Antimicrob Agents Chemother 2010; 54: 1623-1626
    CrossrefSearch in Google Scholar
  • 19 Kojima A, Ishii Y, Ishihara K et al. Extended-spectrum-beta-lactamase-producing Escherichia coli strains isolated from farm animals from 1999 to 2002: report from the Japanese Veterinary Antimicrobial Resistance Monitoring Program. Antimicrob Agents Chemother 2005; 49: 3533-3537
    CrossrefSearch in Google Scholar
  • 20 Smet A, Martel A, Persoons D et al. Diversity of extended-spectrum beta-lactamases and class C beta-lactamases among cloacal Escherichia coli Isolates in Belgian broiler farms. Antimicrob Agents Chemother 2008; 52: 1238-1243
    CrossrefSearch in Google Scholar
  • 21 Dierikx C, van Essen-Zandbergen A, Veldman K et al. Increased detection of extended spectrum beta-lactamase producing Salmonella enterica and Escherichia coli isolates from poultry. Vet Microbiol 2010; 145: 273-278
    CrossrefSearch in Google Scholar
  • 22 Dolejska M, Matulova M, Kohoutova L et al. Extended-spectrum beta-lactamase-producing Escherichia coli in turkey meat production farms in the Czech Republic: national survey reveals widespread isolates with bla(SHV-12) genes on IncFII plasmids. Lett Appl Microbiol 2011; 53: 271-277
    CrossrefSearch in Google Scholar
  • 23 Randall LP, Clouting C, Horton RA et al. Prevalence of Escherichia coli carrying extended-spectrum beta-lactamases (CTX-M and TEM-52) from broiler chickens and turkeys in Great Britain between 2006 and 2009. J Antimicrob Chemother 2011; 66: 86-95
    CrossrefSearch in Google Scholar
  • 24 Riano I, Moreno MA, Teshager T et al. Detection and characterization of extended-spectrum beta-lactamases in Salmonella enterica strains of healthy food animals in Spain. J Antimicrob Chemother 2006; 58: 844-847
    CrossrefSearch in Google Scholar
  • 25 Girlich D, Poirel L, Carattoli A et al. Extended-spectrum beta-lactamase CTX-M-1 in Escherichia coli isolates from healthy poultry in France. Appl Environ Microbiol 2007; 73: 4681-4685
    CrossrefSearch in Google Scholar
  • 26 Costa D, Vinue L, Poeta P et al. Prevalence of extended-spectrum beta-lactamase-producing Escherichia coli isolates in faecal samples of broilers. Vet Microbiol 2009; 138: 339-344
    CrossrefSearch in Google Scholar
  • 27 Geser N, Stephan R, Hachler H. Occurrence and characteristics of extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae in food producing animals, minced meat, and raw milk. BMC Vet Res 2012; 8: 21
    CrossrefSearch in Google Scholar
  • 28 Agersø Y, Borck Høg B, Jensen LB et al. Use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, food and humans in Denmark. In: Korsgaard H, eds. DANMAP 2010. Søborg, Copenhagen: Technical University of Denmark; 2010. Im Internet: http://www.danmap.org/Downloads/Reports.aspx (Stand: 24.1.13)
    Search in Google Scholar
  • 29 Mevius DJ, Koene MGJ, Wit B et al. MARAN 2009 – Monitoring of antimicrobial resistance and antibiotic usage in animals in the Netherlands in 2009. Wageningen: University of Wageningen; 2011. Im Internet: http://www.wageningenur.nl/nl/Publicatie-details.htm?publicationId=publication-way-343035323134 (Stand: 24.1.13)
    Search in Google Scholar
  • 30 Dierikx C, van der Goot J, Fabri T et al. Extended-spectrum-beta-lactamase- and AmpC-beta-lactamase-producing Escherichia coli in Dutch broilers and broiler farmers. J Antimicrob Chemother 2013; 68: 60-67
    CrossrefSearch in Google Scholar
  • 31 Smet A, Martel A, Persoons D et al. Broad-spectrum beta-lactamases among Enterobacteriaceae of animal origin: molecular aspects, mobility and impact on public health. FEMS Microbiol Rev 2009; 34: 295-316
    Search in Google Scholar
  • 32 Aarestrup FM, Hasman H, Agersø Y et al. First description of blaCTX-M-1-carrying Escherichia coli isolates in Danish primary food production. J Antimicrob Chemother 2006; 57: 1258-1259
    CrossrefSearch in Google Scholar
  • 33 Brinas L, Moreno MA, Teshager T et al. Monitoring and characterization of extended-spectrum beta-lactamases in Escherichia coli strains from healthy and sick animals in Spain in 2003. Antimicrob Agents Chemother 2005; 49: 1262-1264
    CrossrefSearch in Google Scholar
  • 34 Hansen KH, Damborg P, Andreasen M et al. Carriage and fecal counts of cefotaxime M-producing Escherichia coli in pigs: a longitudinal study. Appl Environ Microbiol 2013; 79: 794-798
    CrossrefSearch in Google Scholar
  • 35 Wu S, Chouliara E, Hasman H et al. Detection of a single isolate of CTX-M-1-producing Escherichia coli from healthy pigs in Denmark. J Antimicrob Chemother 2008; 61: 747-749
    CrossrefSearch in Google Scholar
  • 36 Escudero E, Vinue L, Teshager T et al. Resistance mechanisms and farm-level distribution of fecal Escherichia coli isolates resistant to extended-spectrum cephalosporins in pigs in Spain. Res Vet Sci 2010; 88: 83-87
    CrossrefSearch in Google Scholar
  • 37 Goncalves A, Torres C, Silva N et al. Genetic characterization of extended-spectrum beta-lactamases in Escherichia coli isolates of pigs from a Portuguese intensive swine farm. Foodborne Pathog Dis 2010; 7: 1569-1573
    CrossrefSearch in Google Scholar
  • 38 Agersø Y, Aarestrup FM, Pedersen K et al. Prevalence of extended-spectrum cephalosporinase (ESC)-producing Escherichia coli in Danish slaughter pigs and retail meat identified by selective enrichment and association with cephalosporin usage. J Antimicrob Chemother 2012; 67: 582-588
    CrossrefSearch in Google Scholar
  • 39 Geser N, Stephan R, Kuhnert P et al. Fecal carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae in swine and cattle at slaughter in Switzerland. J Food Prot 2011; 74: 446-449
    CrossrefSearch in Google Scholar
  • 40 Büchter B. Vorkommen und Charakterisierung von Extended-Spectrum-Beta-Laktamase (ESBL)-produzierenden Escherichia coli bei Lebensmittel liefernden Tieren [Dissertation]. Berlin: Freie Universität Berlin; 2010
    Search in Google Scholar
  • 41 Wieler LH, Semmler T, Eichhorn I et al. No evidence of the Shiga toxin-producing E. coli O104:H4 outbreak strain or enteroaggregative E. coli (EAEC) found in cattle faeces in northern Germany, the hotspot of the 2011 HUS outbreak area. Gut Pathog 2011; 3: 17
    CrossrefSearch in Google Scholar
  • 42 Snow LC, Wearing H, Stephenson B et al. Investigation of the presence of ESBL-producing Escherichia coli in the North Wales and West Midlands areas of the UK in 2007 to 2008 using scanning surveillance. Vet Rec 2011; 169: 656
    CrossrefSearch in Google Scholar
  • 43 Madec JY, Lazizzera C, Chatre P et al. Prevalence of fecal carriage of acquired expanded-spectrum cephalosporin resistance in Enterobacteriaceae strains from cattle in France. J Clin Microbiol 2008; 46: 1566-1567
    CrossrefSearch in Google Scholar
  • 44 Endimiani A, Bertschy I, Perreten V. Escherichia coli producing CMY-2 beta-lactamase in bovine mastitis milk. J Food Prot 2012; 75: 137-138
    CrossrefSearch in Google Scholar
  • 45 Shiraki Y, Shibata N, Doi Y et al. Escherichia coli producing CTX-M-2 beta-lactamase in cattle, Japan. Emerg Infect Dis 2004; 10: 69-75
    CrossrefSearch in Google Scholar
  • 46 Friese A, Schulz J, Laube H et al. Faecal occurrence and emissions of livestock-associated methicillin-resistant Staphylococcus aureus (laMRSA) and ESBL/AmpC-producing E. coli from animal farms in Germany. Berl Münch Tierärztl Wochenschr
  • 47 Kola A, Kohler C, Pfeifer Y et al. High prevalence of extended-spectrum-beta-lactamase-producing Enterobacteriaceae in organic and conventional retail chicken meat, Germany. J Antimicrob Chemother 2012;
    Search in Google Scholar
  • 48 Leverstein-van Hall MA, Dierikx CM, Cohen Stuart J et al. Dutch patients, retail chicken meat and poultry share the same ESBL genes, plasmids and strains. Clin Microbiol Infect 2011; 17: 873-880
    CrossrefSearch in Google Scholar
  • 49 Overdevest I, Willemsen I, Rijnsburger M et al. Extended-spectrum beta-lactamase genes of Escherichia coli in chicken meat and humans, The Netherlands. Emerg Infect Dis 2011; 17: 1216-1222
    CrossrefSearch in Google Scholar
  • 50 Kirchner M, Wearing H, Hopkins KL et al. Characterization of plasmids encoding cefotaximases group 1 enzymes in Escherichia coli recovered from cattle in England and Wales. Microb Drug Resist 2011; 17: 463-470
    CrossrefSearch in Google Scholar
  • 51 Warren RE, Ensor VM, O'Neill P et al. Imported chicken meat as a potential source of quinolone-resistant Escherichia coli producing extended-spectrum beta-lactamases in the UK. J Antimicrob Chemother 2008; 61: 504-508
    CrossrefSearch in Google Scholar
  • 52 Cohen Stuart J, van den Munckhof T, Voets G et al. Comparison of ESBL contamination in organic and conventional retail chicken meat. Int J Food Microbiol 2012; 154: 212-214
    CrossrefSearch in Google Scholar
  • 53 Kreausukon K. Einsatz von Antibiotika in 60 Milchrinderbetrieben in Norddeutschland und Charakterisierung von Methicillin-resistenten Staphylococcus aureus (MRSA) und Extended-Spectrum Beta-Lactamase produzierenden Escherichia coli (ESBL produzierende E. coli) [Dissertation]. Berlin: Freie Universität Berlin; 2011
    Search in Google Scholar
  • 54 Dolejska M, Jurcickova Z, Literak I et al. IncN plasmids carrying bla CTX-M-1 in Escherichia coli isolates on a dairy farm. Vet Microbiol 2011; 149: 513-516
    CrossrefSearch in Google Scholar
  • 55 Walther B, Hermes J, Cuny C et al. Sharing more than friendship--nasal colonization with coagulase-positive staphylococci (CPS) and co-habitation aspects of dogs and their owners. PLoS One 2012; 7: e35197
    CrossrefSearch in Google Scholar
  • 56 MARAN. Monitoring of Antimicrobial Resistance and Antibiotic Usage in Animals in the Netherlands in 2010/2011. Wageningen: University of Wageningen; 2012
    Search in Google Scholar