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Semin Thromb Hemost 2012; 38(07): 652-660
DOI: 10.1055/s-0032-1326781
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Perioperative Management of Patients Having Noncardiac Surgery Who Are Receiving Anticoagulant or Antiplatelet Therapy: An Evidence-Based but Practical Approach

Saeed Darvish-Kazem
1   Department of Medicine, McMaster University, Internal Medicine Residency Office, Hamilton, Ontario, Canada
,
James D. Douketis
2   Department of Medicine, McMaster University and St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada
› Author Affiliations
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Publication History

Publication Date:
03 October 2012 (online)

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Abstract

Patients receiving anticoagulant or antiplatelet therapy who require noncardiac surgery represent a common yet challenging clinical problem. Clinicians must balance the risk of thromboembolic and major adverse cardiovascular events that are associated with interrupting these therapies, against the risk of bleeding from continuing these drugs in the perioperative period. Identifying patients at highest risk for such complications requires particular attention to the role of bridging therapy and the optimal timing and duration of drug withdrawal and resumption with surgery. Patients with coronary stents represent a population that requires specific considerations, due to the added risk and significant mortality associated with perioperative stent thrombosis. Minimizing this risk is dependent on several patient- and stent-specific factors. This review provides clinicians with a summary of the available evidence to facilitate a practical approach to the management of these patients while highlighting the need for continued research in this field.

Keywords

perioperative - antiplatelet - anticoagulant - noncardiac surgery - bridging anticoagulation
 

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