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Arzneimittelforschung 2012; 62(12): 599-602
DOI: 10.1055/s-0032-1327677
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Interaction of 5-amino-1,3,4-thiadiazole-2-thiol and its Violuric Acid Adduct with Pt(II) – Crystals Structures, Spectroscopic Properties and Cytotoxic Activity

M. Kavlakova
1   Department of Chemistry, Faculty of Pharmacy, Medical University, Sofia, Bulgaria
,
A. Bakalova
1   Department of Chemistry, Faculty of Pharmacy, Medical University, Sofia, Bulgaria
,
G. Momekov
2   Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University, Sofia, Bulgaria
,
D. Ivanov
1   Department of Chemistry, Faculty of Pharmacy, Medical University, Sofia, Bulgaria
› Author Affiliations
Further Information

Publication History

received 28 March 2012

accepted 29 September 2012

Publication Date:
23 October 2012 (online)

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Abstract

The coordination properties of Pt(II) with 5-amino-1,3,4-thiadiazole-2-thiol [CAS 2349-67-9] (L 1 ) and its novel violurate adduct (L 2 ), both in solution and in solid state, are studied by means of conventional IR-spectroscopy, single crystal X-ray diffraction and thermal methods. The complex compounds of L 1 and L 2 , with general formulas [Pt(C2H2N3S2)2] and [Pt(C6H4N6S2O3)(Cl)]Cl respectively, are obtained. Quantum chemical calculations of the ligands are performed with a view to obtain electronic structure and optical properties of the ligands L 1 and L 2 , respectively. The cell viability of the ligands and metal complexes on a panel of human tumor cell lines is evaluated.

Key words

5-amino-1,3,4-thiadiazole - violurate adduct - Pt (II) complexes - spectroscopic and structural elucidation - cytotoxic activity
 

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