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DOI: 10.1055/s-0032-1327877
Isolation of Antithrombotic Phenolic Compounds from the Leaves of Crataegus pinnatifida
Publikationsverlauf
received 19. April 2012
revised 27. August 2012
accepted 29. September 2012
Publikationsdatum:
31. Oktober 2012 (online)
![](https://www.thieme-connect.de/media/plantamedica/201218/lookinside/thumbnails/10.1055-s-0032-1327877-1.jpg)
Abstract
Four novel phenolic compounds (1–4) were isolated from the leaves of Crataegus pinnatifida, along with three known ones (5–7). Their structures were elucidated as: methyl 4-O-β-D-glucopyranosyl-3-[(2E,6E)-8-O-β-D-glucopyranosyl-3,7-dimethyl-2,6-octadienyl] benzoate (1), biphenyl-5-ol-3-O-β-D-glucoside (2), 3,4′-dimethoxy-biphenyl-5-ol-4-O-β-D-glucoside (3), (E)-6-(benzoyloxy)-1-hydroxyhex-3-en-2-O-β-D-glucoside (4), shanyenoside A (5), eriodectyol (6), and 2″-O-rhamnosyl vitexin (7), using a combination of mass spectroscopy, 1D and 2D NMR spectroscopy, and chemical analysis. The antithrombotic activity of the isolated compounds was investigated on the transgenic zebra fish system. Among them, eriodectyol (6) potently inhibited the production of thrombus.
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