Neuroprotective Lignans from the Stems of Schisandra glaucescens

Heng-Yi Yu; Cui Hao; Fan-Yu Meng; Xue Li; Zu-Yu Chen; Xi Liang; Han-Li Ruan

doi:10.1055/s-0032-1327895

Planta Medica, Inhaltsverzeichnis

Planta Med 2012; 78(18): 1962-1966
DOI: 10.1055/s-0032-1327895

Natural Product Chemistry

Letters

Georg Thieme Verlag KG Stuttgart · New York

Neuroprotective Lignans from the Stems of Schisandra glaucescens

Heng-Yi Yu

¹Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Peopleʼs Republic of China

,

Cui Hao

¹Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Peopleʼs Republic of China

,

Fan-Yu Meng

¹Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Peopleʼs Republic of China

,

Xue Li

¹Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Peopleʼs Republic of China

,

Zu-Yu Chen

¹Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Peopleʼs Republic of China

,

Xi Liang

¹Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Peopleʼs Republic of China

,

Han-Li Ruan

¹Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Peopleʼs Republic of China

› Institutsangaben

Abstract

Two new tetrahydrofuran lignans, schiglaucin A and B (1–2), together with eight known analogues (3–10), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic techniques (HRESIMS, UV, IR, NMR, and CD experiments). All of the compounds were tested for their neuroprotective activities against H₂O₂- and CoCl₂-induced cell injuries in SH-SY5Y cells, respectively. Compounds 1–10 showed significant neuroprotective effects against H₂O₂-induced SH-SY5Y cell death, while compounds 1–5 and 8–10 exhibited significant neuroprotective effects against CoCl₂-induced SH-SY5Y cell injury.

Key words

Schisandra glaucescens Diels. - Schisandraceae - lignans - schiglaucin A - schiglaucin B - neuroprotective

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Referenzen

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