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DOI: 10.1055/s-0032-1327895
Neuroprotective Lignans from the Stems of Schisandra glaucescens
Publikationsverlauf
received 08. Februar 2012
revised 26. Juli 2012
accepted 08. Oktober 2012
Publikationsdatum:
13. November 2012 (online)
![](https://www.thieme-connect.de/media/plantamedica/201218/lookinside/thumbnails/10.1055-s-0032-1327895-1.jpg)
Abstract
Two new tetrahydrofuran lignans, schiglaucin A and B (1–2), together with eight known analogues (3–10), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic techniques (HRESIMS, UV, IR, NMR, and CD experiments). All of the compounds were tested for their neuroprotective activities against H2O2- and CoCl2-induced cell injuries in SH-SY5Y cells, respectively. Compounds 1–10 showed significant neuroprotective effects against H2O2-induced SH-SY5Y cell death, while compounds 1–5 and 8–10 exhibited significant neuroprotective effects against CoCl2-induced SH-SY5Y cell injury.
Key words
Schisandra glaucescens Diels. - Schisandraceae - lignans - schiglaucin A - schiglaucin B - neuroprotective-
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