Eleven new triterpene saponins, ilexpublesnins C–M (1–11), along with ten known analogues were isolated from the roots of Ilex pubescens. Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments. Compounds 1, 2, 10, and 11 contain a 24-aldehyde, which is rare for triterpene saponins from Ilex. These compounds were evaluated in vitro for their cytotoxic effects on human cancer cell lines HepG2, HLE, BEL7402, BEL7403, BEL7405, MCF-7, and HeLa. Among them, only compounds 6 and 19 showed cytotoxicity against the MCF-7 cell line [inhibition (%): 33.14 and 34.03, respectively].
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. Helv Chim Acta 2008; 91: 1244-1250
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10 Zheng J, Tang L, Xian XD, Zhou SX, Shi HM, Jiang Y, Gu YQ, Liu G, Tu PF. Inhibitory effect of triterpenoid saponins from the leaves of Ilex kudingcha on aggregated LDL-induced lipid deposition in macrophages. Planta Med 2009; 75: 1410-1414
11 Zheng J, Wang X, Li H, Gu YQ, Tu PF, Wen Z. Improving abnormal hemorheological parameters in ApoE-/- mice by Ilex total saponins. Clin Hemorheol Microcirc 2009; 42: 29-36
14 Zhou SX, Yang J, Liu F, Tu PF. Complete assignments of 1H and 13C NMR spectroscopic data for two new triterpenoid saponins from Ilex hainanensis
. Magn Reson Chem 2007; 45: 179-181
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