Abstract
Phytochemical investigation of the aerial parts of Prinsepia utilis
Royle resulted in the isolation and identification of ten pentacyclic
triterpenoids, including two new triterpenoids,
2α-O-trans-p-coumaroyl-3β,19α-dihydroxy-urs-12-en-28-oic
acid (1) and
2α-O-cis-p-coumaroyl-3β,19α-dihydroxy-urs-12-en-28-oic
acid (2), along with eight known pentacyclic triterpenoids
(3–10). The structures were elucidated by extensive
spectroscopic methods and by comparison to previously reported spectroscopic
data. Most of these compounds showed significant cytotoxic activities
against four human cancer cell lines (A549, HCT116, MDA-MB-231, and
CCRF-CEM), and the structure-activity relationships are also discussed.
Key words
Prinsepia utilis
- Rosaceae - triterpenoids - cytotoxicity
