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Planta Med 2013; 79(11): 897-908
DOI: 10.1055/s-0032-1328656
Reviews
Georg Thieme Verlag KG Stuttgart · New York

Application of Plant Metabonomics in Quality Assessment for Large-Scale Production of Traditional Chinese Medicine

Zhangchi Ning
1   School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China
,
Cheng Lu
2   Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China
,
Yuxin Zhang
1   School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China
,
Siyu Zhao
1   School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China
,
Baoqin Liu
3   Zhengzhou Hospital of Traditional Chinese Medicine, Zhengzhou, China
,
Xuegong Xu
3   Zhengzhou Hospital of Traditional Chinese Medicine, Zhengzhou, China
,
Yuanyan Liu
1   School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China
› Institutsangaben
Weitere Informationen

Publikationsverlauf

received 13. Oktober 2012
revised 06. Mai 2013

accepted 12. Mai 2013

Publikationsdatum:
27. Juni 2013 (online)

Auch verfügbar auf
   Lizenzen und Reprints

Abstract

The curative effects of traditional Chinese medicines are principally based on the synergic effect of their multi-targeting, multi-ingredient preparations, in contrast to modern pharmacology and drug development that often focus on a single chemical entity. Therefore, the method employing a few markers or pharmacologically active constituents to assess the quality and authenticity of the complex preparations has a number of severe challenges. Metabonomics can provide an effective platform for complex sample analysis. It is also reported to be applied to the quality analysis of the traditional Chinese medicine. Metabonomics enables comprehensive assessment of complex traditional Chinese medicines or herbal remedies and sample classification of diverse biological statuses, origins, or qualities in samples, by means of chemometrics. Identification, processing, and pharmaceutical preparation are the main procedures in the large-scale production of Chinese medicinal preparations. Through complete scans, plants metabonomics addresses some of the shortfalls of single analyses and presents a considerable potential to become a sharp tool for traditional Chinese medicine quality assessment.

Key words

plant metabonomics - large-scale production - discrimination - processing - pharmaceutics
 

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