Triterpene Saponins from Clematis mandshurica and Their
                    Antiproliferative Activity

Yi-xia Gong; Hui-ming Hua; Yong-nan Xu; Jian-yu Liu; Zong-gui Yu; Jing Ma; Hui Zhang; Yong-kui Jing

doi:10.1055/s-0032-1328657

Planta Medica, Inhaltsverzeichnis

Planta Med 2013; 79(11): 987-994
DOI: 10.1055/s-0032-1328657

Natural Product Chemistry

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Triterpene Saponins from Clematis mandshurica and Their Antiproliferative Activity

Yi-xia Gong

¹Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China

²School of Tradition Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, PR China

,

Hui-ming Hua

¹Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China

²School of Tradition Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, PR China

,

Yong-nan Xu

¹Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China

³School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, PR China

,

Jian-yu Liu

¹Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China

³School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, PR China

,

Zong-gui Yu

¹Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China

²School of Tradition Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, PR China

,

Jing Ma

¹Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China

²School of Tradition Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, PR China

,

Hui Zhang

¹Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China

³School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, PR China

,

Yong-kui Jing

⁴Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA

› Institutsangaben

Abstract

Six new triterpene saponins, clematomandshurica saponins F–K (1–6), together with a known compound (7), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis. Compounds 5–7 exhibited antiproliferative effects against PC-3 human prostate cancer cells with GI₅₀ values of 1.29, 1.50, and 0.71 µM, respectively.

Key words

Clematis mandshurica - Ranunculaceae - triterpene saponins - antiproliferative activity - prostate cancer PC-3

Volltext

Referenzen

References
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