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Semin Thromb Hemost 2012; 38(08): 839-844
DOI: 10.1055/s-0032-1328886
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Drug-Associated Thrombotic Microangiopathies

Justin Kreuter
1   Division of Transfusion Medicine, Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, Minnesota
,
Jeffrey L. Winters
2   Division of Transfusion Medicine and Therapeutic Apheresis Treatment Unit, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota
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Publikationsverlauf

Publikationsdatum:
04. Oktober 2012 (online)

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Abstract

Thrombotic microangiopathy is a pathological process that results in thrombocytopenia, schistocytes, and organ ischemia. A wide variety of causes of thrombotic microangiopathy have been described, each associated with a different pathological stimulus and predisposition toward certain vascular territories. This review will summarize our understanding of key drugs that have been classically and newly associated with thrombotic microangiopathy as well as mention of treatment options focusing on the role of plasma exchange.

Keywords

drug - thrombotic microangiopathy - plasma exchange
 

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