Qualität der Screening-Koloskopie: Positionspapier der Europäischen Gesellschaft für Gastrointestinale Endoskopie

B. Rembacken; C. Hassan; J. F. Riemann; A. Chilton; M. Rutter; J.-M. Dumonceau; M. Omar; T. Ponchon

doi:10.1055/s-0032-1330382

Endoskopie heute, Table of Contents

Endoskopie heute 2012; 25(4): 276-288
DOI: 10.1055/s-0032-1330382

Leitlinie

Qualität der Screening-Koloskopie: Positionspapier der Europäischen Gesellschaft für Gastrointestinale Endoskopie

Quality in Screening Colonoscopy: Position Statement of the European Society of Gastrointestinal Endoscopy (ESGE)

Authors

B. Rembacken

¹Centre for Digestive Diseases, Department of Gastroenterology, The General Infirmary at Leeds, Leeds, United Kingdom
C. Hassan

²Digestive Endoscopy Unit, Catholic University, Rome, Italy
J. F. Riemann

³Stiftung Lebensblicke, Klinikum Ludwigshafen, Ludwigshafen Germany
A. Chilton

⁴Department of Gastroenterology, Kettering General Hospital, Kettering, United Kingdom
M. Rutter

⁵Department of Gastroenterology, University Hospital of North Tees, Stockton-on-Tees, United Kingdom

⁶Durham University, County Durham, UK
J.-M. Dumonceau

⁷Department of Gastroenterology, HUG, Geneva, Switzerland
M. Omar

⁸Department of Internal Medicine, Digestive Diseases and Endoscopy, New Mowasat Hospital, Salmiya, Kuwait
T. Ponchon

⁹Department of Hepatogastroenterology, Edouard Herriot Hospital, Lyon, France

Abstract

Schlüsselwörter

Einverständnis - Darmreinigung - Sedierung - Zökum-Intubationsrate - Adenom- und Karzinomdetektion - Intervall-Läsionen - Komplikationen

Key words

consens - bowel cleansing - Sedation - cecal intubation rate - adenoma/cancerdetection - interval lesions - complications

Full Text

References

Literatur
1 Benson VS, Patnick J, Davies AK et al. International Colorectal Cancer Screening Network. Colorectal cancer screening: a comparison of 35 initiatives in 17 countries. Int J Cancer 2008; 122: 1357-1367
2 Wennberg JE. Time to tackle unwarranted variations in practice. BMJ 2011; 342: 687-690
3 Eisinger F, Cals L, Calazel-Benque A et al. Impact of organised programs on colorectal cancer screening. BMC Cancer 2008; 8: 104
4 Bos AB, van Ballegooijen M, van Gessel-Dabekaussen AA et al. Organised cervical cancer screening still leads to higher coverage than spontaneous screening in The Netherlands. Eur J Cancer 1998; 34: 1598-1601
5 Ronco G, Pilutti S, Patriarca S et al. Impact of the introduction of organised screening for cervical cancer in Turin, Italy: cancer incidence by screening history 1992–98. Br J Cancer 2005; 93: 376-378
6 Ronco G, Segnan N, Giordano L et al. Interaction of spontaneous and organised screening for cervical cancer in Turin, Italy. Eur J Cancer 1997; 33: 1262-1267
7 Nygard JF, Skare GB, Thoresen SO. The cervical cancer screening programme in Norway, 1992–2000: changes in Pap smear coverage and incidence of cervical cancer. J Med Screen 2002; 9: 86-91
8 Lynge E, Clausen LB, Guignard R et al. What happens when organization of cervical cancer screening is delayed or stopped?. J Med Screen 2006; 13: 41-46
9 Nieminen P, Kallio M, Anttila A et al. Organised vs. spontaneous Pap-smear screening for cervical cancer: A case-control study. Int J Cancer 1999; 83: 55-58
10 Quinn M, Babb P, Jones J et al. Effect of screening on incidence of and mortality from cancer of cervix in England: evaluation based on routinely collected statistics. BMJ 1999; 318: 904-908
11 Chamot E, Charvet AI, Perneger TV. Who gets screened, and where: a comparison of organised and opportunistic mammography screening in Geneva, Switzerland. Eur J Cancer 2007; 43: 576-584
12 Puliti D, Miccinesi G, Collina N et al. Effectiveness of service screening: a case–control study to assess breast cancer mortality reduction. Br J Cancer 2008; 99: 423-427
13 International Agency for Research on Cancer. Cervix cancer screening. IARC Handbooks of cancer prevention. Lyon, France: IARC Press; 2005 Volume 10.
14 Hardcastle JD, Chamberlain JO, Robinson MH et al. Randomised controlled trial of faecal-occult-blood screening for colorectal cancer. Lancet 1996; 348: 1472-1477
15 Kronborg O, Fenger C, Olsen J et al. Randomised study of screening for colorectal cancer with faecal-occult-blood test. Lancet 1996; 348: 1467-1471
16 Mandel JS, Bond JH, Church TR et al. Reducing mortality from colorectal cancer by screening for faecal occult blood. Minnesota Colon Cancer Control Study. N Engl J Med 1993; 328: 1365-1371
17 Lindholm E, Brevinge H, Haglind E. Survival benefit in a randomized clinical trial of faecal occult blood screening for colorectal cancer. Br J Surg 2008; 95: 1029-1036
18 Kewenter J, Breving H, Engaras B et al. Results of screening, rescreening, and follow-up in a prospective randomized study for detection of colorectal cancer by faecal occult blood testing. Scand J Gastroenterol 1994; 29: 468-473
19 Council of the European Union. Council Recommendation of 2 December 2003 on cancer screening (2003/87/EC): OJ L327/34–38. Brussels: 2003
20 Atkin WS, Edwards R, Kralj-Hans I et al. Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial. Lancet 2010; 375: 1624-1633
21 Segnan N, Senore C, Andreoni B et al. Baseline findings of the Italian multicenter randomized controlled trial of “once-only sigmoidoscopy” – SCORE. J Natl Cancer Inst 2002; 94: 1763-1772
22 Weissfeld J, Schoen R, Pinsky P et al. Flexible sigmoidoscopy in the PLCO cancer screening trial: results from the baseline screening examination of a randomized trial. J Natl Cancer Inst 2005; 97: 989-997
23 Segnan N, Patnick J, von Karsa L (eds), European Commission European guidelines for quality assurance in colorectal cancer screening and diagnosis – first edition. Luxembourg: Publications Office of the European Union; 2011
24 Bourke MJ. Making every colonoscopy count: ensuring quality in endoscopy. J Gastroenterol Hepatol 2009; 24: S43-50
25 Hoff G, Bretthauer M, Huppertz-Hauss G et al. The Norwegian Gastronet project: Continuous quality improvement of colonoscopy in 14 Norwegian centres. Scand J Gastroenterol 2006; 41: 481-487
26 Seip B, Bretthauer M, Dahler S et al. Sustaining the vitality of colonoscopy quality improvement programmes over time. Experience from the Norwegian Gastronet programme. Scand J Gastroenterol 2010; 45: 362-369
27 Burke CA, Church JM. Enhancing the quality of colonoscopy: the importance of bowel purgatives. Gastrointest Endosc 2007; 66: 565-573
28 Froehlich F, Wietlisbach V, Gonvers JJ et al. Impact of colonic cleansing on quality and diagnostic yield of colonoscopy: the European Panel of Appropriateness of Gastrointestinal Endoscopy European multicenter study. Gastrointest Endosc 2005; 61: 378-384
29 Harewood GC, Sharma VK, de Garmo P. Impact of colonoscopy preparation quality on detection of suspected colonic neoplasia. Gastrointest Endosc 2003; 58: 76-79
30 Thomas-Gibson S, Rogers P, Cooper S et al. Judgement of the quality of bowel preparation at screening flexible sigmoidoscopy is associated with variability in adenoma detection rates. Endoscopy 2006; 38: 456-460
31 Hookey LC, Vanner S. A review of current issues underlying colon cleansing before colonoscopy. Can J Gastroenterol 2007; 21: 105-111
32 Hawes RH, Lowry A, Deziel D. A consensus document on bowel preparation before colonoscopy. Gastrointest Endosc 2006; 63: 894-909
33 World Health Organization. WHO Pharmaceuticals Newsletter 2009 No.1. Geneva: WHO.
34 Belsey J, Epstein O, Heresbach D. Systematic review: oral bowel preparation for colonoscopy. Aliment Pharmacol Ther 2007; 25: 373-384
35 Rex DK, Vanner SJ. Colon cleansing before colonoscopy: does oral sodium phosphate solution still make sense?. Can J Gastroenterol 2009; 23: 210-214
36 Frommer D. Cleansing ability and tolerance of three bowel preparations for colonoscopy. Dis Colon Rectum 1997; 40: 100-104
37 Hamilton D, Mulcahy D, Walsh D et al. Sodium picosulphate compared with polyethylene glycol solution for large bowel lavage: a prospective randomised trial. Br J Clin Pract 1996; 50: 73-75
38 Golub RW, Kerner BA, Wise Jr WE. Colonoscopic preparations – which one? A blinded, prospective, randomized trial. Dis Colon Rectum 1995; 58: 594-597
39 Rösch T, Classen M. Fractional cleansing of the large bowel with Golytely for colonoscopic preparations: a controlled trial. Endoscopy 1987; 19: 198-200
40 Kilgore TW, Abdinoor AA, Szary NM et al. Bowel preparation with split-dose polyethylene glycol before colonoscopy: a meta-analysis of randomized controlled trials. Gastrointest Endosc 2011; 73: 1240-1245
41 Aoun E, Baki HA, Azar C et al. A randomized single-blind trial of split-dose PEG-electrolyte solution without dietary restriction compared with whole dose PEG-electrolyte solution with dietary restriction for colonoscopy preparation. Gastrointest Endosc 2005; 62: 213-218
42 El Sayed AMA, Kanafani ZA, Mourad FH et al. A randomized single-blind trial of whole versus split-dose polyethylene glycol-electrolyte solution for colonoscopy preparation. Gastrointest Endosc 2003; 58: 36-40
43 Park SS, Sinn DH, Kim YH et al. Efficacy and tolerability of split-dose magnesium citrate: low-volume (2 liters) polyethylene glycol vs. single- or split-dose polyethylene glycol bowel preparation for morning colonoscopy. Am J Gastroenterol 2010; 105: 1319-1326
44 Cohen SM, Wexner SD, Binderow SR et al. Prospective, randomized, endoscopic-blinded trial comparing pre-colonoscopy bowel cleansing methods. Dis Colon Rectum 1994; 37: 689-696
45 Cohen LB, Sanyal SM, von Althann C et al. Clinical trial: 2-L polyethylene glycol-based lavage solutions for colonoscopy preparation – a randomized, single-blind study of two formulations. Aliment Pharmacol Ther 2010; 32: 637-644
46 Afridi S, Barthel J, King P et al. Prospective, randomized trial comparing a new sodium phosphate-bisacodyl regimen with conventional PEG-ES lavage for outpatient colonoscopy preparation. Gastrointest Endosc 1995; 41: 485-489
47 Berkelhammer C, Ekambaram A, Silva R. Low-volume oral colonoscopy bowel preparation: sodium phosphate and magnesium citrate. Gastrointest Endosc 2002; 56: 89-94
48 Clarkston W, Tsen T, Dies D et al. Oral sodium phosphate versus sulfate-free polyethylene glycol electrolyte lavage solution in outpatient preparation for colonoscopy: a prospective comparison. Gastrointest Endosc 1996; 43: 42-48
49 Sharma VK, Steinberg EN, Vasudeva R et al. Randomized, controlled study of pre-treatment with magnesium citrate on the quality of colonoscopy preparation with polyethylene glycol electrolyte lavage solution. Gastrointest Endosc 1997; 46: 541-543
50 Rostom A, Jolicoeur E. Validation of a new scale for the assessment of bowel preparation quality. Gastrointest Endosc 2004; 59: 482-486
51 Lai EJ, Calderwood AH, Doros G et al. The Boston bowel preparation scale: a valid and reliable instrument for colonoscopy-orientated research. Gastrointest Endosc 2009; 69: 620-625
52 Eckardt VF, Kanzler G, Schmitt T et al. Complications and adverse effects of colonoscopy with selective sedation. Gastrointest Endosc 1999; 49: 560-565
53 Rex DK. Colonoscopy. Gastrointest Endosc Clin N Am 2000; 10: 135-160
54 Rex DK, Imperiale TF, Portish V. Patients willing to try colonoscopy without sedation: associated clinical factors and results of a randomized controlled trial. Gastrointest Endosc 1999; 49: 554-559
55 Riphaus A, Wehrmann T, Weber B et al. S3 Guideline: Sedation for gastrointestinal endoscopy 2008. Endoscopy 2009; 41: 787-815
56 McQuaid KR, Laine L. A systematic review and meta-analysis of randomized, controlled trials of moderate sedation for routine endoscopic procedures. Gastrointest Endosc 2008; 67: 910-923
57 Dumonceau JM, Riphaus A, Aparicio JR et al. European Society of Gastrointestinal Endoscopy, European Society of Gastroenterology and Endoscopy Nurses and Associates, and the European Society of Anaesthesiology Guideline: Non-anesthesiologist administration of propofol for GI endoscopy. Endoscopy 2010; 42: 960-974
58 Practice guidelines for sedation and analgesia by non-anesthesiologists – An updated report by the American Society of Anesthesiologists Task Force on Sedation and Analgesia by Non-Anesthesiologists. Anesthesiology 2002; 96: 1004-1017
59 Greenblatt DJ, Allen MD, Shader RI. Toxicity of high-dose flurazepam in the elderly. Clin Pharmacol Ther 1977; 21: 355-361
60 Castleden CM, George CF, Marcer D et al. Increased sensitivity to nitrazepam in old age. Br Med J 1977; i: 10-12
61 Seip B, Bretthauer M, Dahler S et al. Patient satisfaction with on-demand sedation for outpatient colonoscopy. Endoscopy 2010; 42: 639-646
62 Cotton PB, Eisen GM, Aabakken L et al. A lexicon for endoscopic adverse events: report of an ASGE workshop. Gastrointest Endosc 2010; 71: 446-454
63 Froehlich F, Harris JK, Wietlisbach V et al. Current sedation and monitoring practice for colonoscopy: an international observational study (EPAGE). Endoscopy 2006; 38: 461-469
64 Eloubeidi MA, Wallace MB, Desmond R et al. Female gender and other factors predictive of a limited screening flexible sigmoidoscopy examination for colorectal cancer. Am J Gastroenterol 2003; 98: 1634-1639
65 Harris JK, Vader JP, Wietlisbach V et al. Variations in colonoscopy practice in Europe: a multicentre descriptive study (EPAGE). Scand J Gastroenterol 2007; 42: 126-134
66 Rathgaber SW, Wick TM. Colonoscopy completion and complication rates in a community gastroenterology practice. Gastrointest Endosc 2006; 64: 556-562
67 Viiala CH, Olynyk JK. Outcomes for women in a flexible sigmoidoscopy-based colorectal cancer screening programme. Intern Med J 2008; 38: 90-94
68 Othman MO, Bradley AG, Choudhary A et al. Variable stiffness colonoscope versus regular adult colonoscope: meta-analysis of randomized controlled trials. Endoscopy 2009; 41: 17-24
69 Shah SG, Brooker JC, Williams CB et al. Effect of magnetic endoscope imaging on colonoscopy performance: a randomised controlled trial. Lancet 2000; 356: 1718-1722
70 Rutter MD, Chilton A. Quality assurance guidelines for colonoscopy. NHS BCSP Publication 2011; 6: 24
71 European Commission. European guidelines for quality assurance in colorectal cancer screening and diagnosis. European Union. ISBN 978-92-79-16435-4 (Printed version). ISBN 978-92-79-16574-0 (Electronic version) doi:10.2772/1458 (Printed version) doi:10.2772/15379 (Electronic version). Available at 2010 http://screening.iarc.fr/doc/ND3210390ENC.pdf
72 Rex DK, Bond JH, Winawer S et al. Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer. Am J Gastroenterol 2002; 97: 1296-1308
73 Levin B, Lieberman DA, McFarland B et al. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology 2008; 134: 1570-1595
74 Rabeneck L, Rumble RB, Axler J et al. Cancer Care Ontario Colonoscopy Standards: standards and evidentiary base. Can J Gastroenterol 2007; 21: 5D-24D
75 Winawer SJ, Zauber AG, O’Brien MJ et al. Randomized comparison of surveillance intervals after colonoscopic removal of newly diagnosed adenomatous polyps. The National Polyp Study Workgroup. N Engl J Med 1993; 328: 901-906
76 Atkin WS, Edwards R, Kralj-Hans I et al. Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial. Lancet 2010; 375: 1624-1633
77 UK Colorectal Cancer Screening Pilot Group. Results of the first round of a demonstration pilot of screening for colorectal cancer in the United Kingdom. BMJ 2004; 329: 133-135
78 Lieberman DA, Weiss DG, Bond JH et al. Use of colonoscopy to screen asymptomatic adults for colorectal cancer. Veterans Affairs Cooperative Study Group 380. N Engl J Med 2000; 343: 162-168
79 Regula J, Rupinski M, Kraszewska E et al. Colonoscopy in colorectal-cancer screening for detection of advanced neoplasia. N Engl J Med 2006; 355: 1863-1872
80 Schoenfeld P, Cash B, Flood A et al. Colonoscopic screening of average-risk women for colorectal neoplasia. N Engl J Med 2005; 352: 2061-2068
81 Bressler B, Paszat LF, Vinden C et al. Colonoscopic miss rates for right sided colon cancer: a population based analysis. Gastroenterology 2004; 127: 452-456
82 Heresbach D, Barrioz T, Lapalus MG et al. Miss rate for colorectal neoplastic polyps: a prospective multicenter study of back-to-back video colonoscopies. Endoscopy 2008; 40: 284-290
83 Hixson L, Fennerty MB, Sampliner RE et al. Prospective study of the frequency and size distribution of polyps missed by colonoscopy. J Natl Cancer Inst 1990; 82: 1769-1772
84 Chen SC, Rex DK. Endoscopist can be more powerful than age and male gender in predicting adenoma detection at colonoscopy. Am J Gastroenterol 2007; 102: 856-861
85 Atkin W, Rogers P, Cardwell C et al. Wide variation in adenoma detection rates at screening flexible sigmoidoscopy. Gastroenterology 2004; 126: 1247-1256
86 Wilkins T, LeClair B, Smolkin M et al. Screening colonoscopies by primary care physicians: a meta-analysis. Ann Fam Med 2009; 7: 56-62
87 Rex DK, Cutler CS, Lemmel GT et al. Colonoscopic miss rates of adenomas determined by back-to-back colonoscopies. Gastroenterology 1997; 112: 24-28
88 Pickhardt PJ, Nugent PA, Mysliwiec PA et al. Location of adenomas missed by optical colonoscopy. Ann Intern Med 2004; 141: 352-359
89 Karminski MF, Regula JR, Kraszewska E et al. Quality indicators for colonoscopy and the risk of interval cancer. N Engl J Med 2010; 362: 1795-1803
90 Denis B, Sauleau EA, Gendre I et al. Measurement of adenoma detection and discrimination during colonoscopy in routine practice: an exploratory study. Gastrointest Endosc 2011; 74: 1325-1336
91 Imperiale TF, Wagner DR, Lin CY et al. Results of screening colonoscopy among persons 40 to 49 years of age. N Engl J Med 2002; 346: 1781-1785
92 Rundle AG, Lebwohl B, Vogel R et al. Colonoscopic screening in average-risk individuals ages 40 to 49 vs. 50 to 59 years. Gastroenterology 2008; 134: 1311-1315
93 Zheng S, Chen K, Liu X et al. Cluster randomization trial of sequence mass screening for colorectal cancer. Dis Colon Rectum 2003; 46: 51-58
94 Allison JE, Sakoda LC, Levin TR et al. Screening for colorectal neoplasms with new fecal occult blood tests: update on performance characteristics. J Natl Cancer Inst 2007; 99: 1462-1470
95 Dancourt V, Lejeune C, Lepage C et al. Immunochemical faecal occult blood tests are superior to guaiac-based tests for the detection of colorectal neoplasms. Eur J Cancer 2008; 44: 2254-2258
96 Guittet L, Bouvier V, Mariotte N et al. Comparison of a guaiac based and an immunochemical faecal occult blood test in screening for colorectal cancer in a general average risk population. Gut 2007; 56: 210-214
97 Imperiale TF, Ransohoff DF, Itzkowitz SH et al. Fecal DNA versus fecal occult blood for colorectal-cancer screening in an average-risk population. N Engl J Med 2004; 351: 2704-2714
98 Ahlquist DA, Sargent DJ, Levin TR et al. Stool DNA screening for colorectal neoplasia: prospective multicenter comparison with occult blood testing. Gastroenterology 2005; 128: 63
99 Barclay RL, Vicari JJ, Doughty AS et al. Colonoscopic withdrawal times and adenoma detection during screening colonoscopy. N Engl J Med 2006; 355: 2533-2541
100 Simmons DT, Harewood GC, Baron TH et al. Impact of endoscopist withdrawal speed on polyp yield: implications for optimal colonoscopy withdrawal time. Aliment Pharmacol Ther 2006; 24: 965-971
101 Lee TJW, Blanks RG, Rees CJ. Colonoscopy withdrawal time and adenoma detection rate in screening colonoscopy: the optimum average withdrawal time is 10 min. Gut 2011; 60 (Suppl. 01) A44
102 Rex DK. Colonoscopic withdrawal technique is associated with adenoma miss rates. Gastrointest Endosc 2000; 51: 33-36
103 Hewett DG, Rex DK. Cap-fitted colonoscopy: a randomized, tandem colonoscopy study of adenoma miss rates. Gastrointest Endosc 2010; 72: 775-781
104 East JE, Stavrindis M, Thomas-Gibson S et al. A comparative study of standard vs. high definition colonoscopy for adenoma and hyperplastic polyp detection with optimized withdrawal technique. Aliment Pharmacol Ther 2008; 28: 768-776
105 DeMarco DC, Odstrcil E, Lara LF et al. Impact of experience with a retrograde-viewing device on adenoma detection rates and withdrawal times during colonoscopy: the Third Eye Retroscope study group. Gastrointest Endosc 2010; 71: 542-550
106 Brown SR, Baraza W, Hurlstone P. Chromoscopy versus conventional endoscopy for the detection of polyps in the colon and rectum. Cochrane Database Syst Rev 2007; 4: CD006439
107 Kudo S, Lambert R, Allen JI et al. Nonpolypoid neoplastic lesions of the colorectal mucosa. Gastrointest Endosc 2008; 68 (Suppl. 04) S3-S47
108 Pohl J, Nguyen-Tat M, Pech O et al. Computed virtual chromoendoscopy for classification of small colorectal lesions: a prospective comparative study. Am J Gastroenterol 2008; 103: 562-569
109 Emura F, Saito Y, Taniguchi M et al. Further validation of magnifying chromocolonoscopy for differentiating colorectal neoplastic polyps in a health screening center. J Gastroenterol Hepatol 2007; 22: 1722-1727
110 Raghavendra M, Hewett DG, Rex DK. Differentiating adenomas from hyperplastic colorectal polyps: narrowband imaging can be learned in 20 minutes. Gastrointest Endosc 2010; 72: 572-576
111 Fry LC, Lazenby AJ, Mikolaenko I et al. Diagnostic quality of polyps resected by snare polypectomy: does the type of electrosurgical current used matter?. Am J Gastroenterol 2006; 101: 2123-2127
112 Ignjatovic A, East JE, Suzuki N et al. Optical diagnosis of small colorectal polyps at routine colonoscopy (Detect InSpect Characterise Resect and Discard; Discard trial): a prospective cohort study. Lancet Oncology 2009; 10: 1171-1178
113 Hassan C, Pickhardt PJ, Rex DK. A resect and discard strategy would improve cost-effectiveness of colorectal cancer screening. Clin Gastroenterol Hepatol 2010; 8: 865-869
114 Imperiale TF, Glowinski EA, Lin-Cooper C et al. Five-year risk of colorectal neoplasia after negative screening colonoscopy. N Engl J Med 2008; 359: 1218-1224
115 Lakoff J, Paszat LF, Saskin R et al. Risk of developing proximal versus distal colorectal cancer after a negative colonoscopy: a population-based study. Clin Gastroenterol Hepatol 2008; 6: 1117-1121
116 Farrar WD, Sawhney MS, Nelson DB et al. Colorectal cancers found after a complete colonoscopy. Clin Gastroenterol Hepatol 2006; 4: 1259-1264
117 Martinez ME, Baron JA, Lieberman DA et al. A pooled analysis of advanced colorectal neoplasia diagnoses after colonoscopic polypectomy. Gastroenterology 2009; 136: 832-841
118 Loeve F, Ballegooijen M, Boer R et al. Colorectal cancer risk in adenoma patients: a nation-wide study. Int J Cancer 2004; 111: 147-151
119 Bressler B, Paszat L, Chen Z et al. Rates of new or missed colorectal cancers after colonoscopy and their risk. Gastroenterology 2007; 132: 96-102
120 Singh H, Turner D, Xue L et al. Risk of developing colorectal cancer following a negative colonoscopy examination. JAMA 2006; 295: 2366-2373
121 Cotterchio M, Manno M, Klar N et al. Colorectal screening is associated with reduced colorectal cancer risk: a case-control study within the population-based Ontario Familial Colorectal Cancer Registry. Cancer Causes Control 2005; 16: 865-875
122 Brenner H, Hoffmeister M, Arndt V et al. Protection from right and left-sided colorectal neoplasms after colonoscopy: population-based study. J Natl Cancer Instit 2010; 102: 89-95
123 Singh H, Nugent Z, Demers AA et al. Rate and predictors of early/missed colorectal cancers after colonoscopy in Manitoba: a population-based study. Am J Gastroenterol 2010; 105: 2588-2596
124 Baxter NN, Goldwasser MA, Paszat LF et al. Association of colonoscopy and death from colorectal cancer. Ann Intern Med 2009; 150: 1-8
125 Haseman J, Lemmel G, Rahmani E et al. Failure of colonoscopy to detect colorectal cancer: evaluation of 47 cases in 20 hospitals. Gastrointest Endosc 1997; 45: 451-455
126 Farrar W, Sawhney M, Nelson D et al. Colorectal cancers found after a complete colonoscopy. Clin Gastroenterol Hepatol 2006; 4: 1259-1264
127 Robertson DJ, Greenberg ER, Beach M et al. Colorectal cancer in patients under close colonoscopic surveillance. Gastroenterology 2005; 129: 34-41
128 Sawhney MS, Farrar WD, Gudiseva S et al. Microsatellite instability in interval colon cancers. Gastroenterology 2006; 131: 1700-1705
129 Rembacken BJ, Fujii T, Cairns A et al. Flat and depressed colonic neoplasms: a prospective study of 1000 colonoscopies in the UK. Lancet 2000; 355: 1211-1214
130 Rostom A, Jolicoeur E, Dube C et al. A randomised prospective trial comparing different regimens of oral sodium phosphate and polyethylene glycol-based lavage solution in the preparation of patients for colonoscopy. Gastrointest Endosc 2006; 64: 544-552
131 McNicol L, Story DA, Leslie K et al. Postoperative complications and mortality in older patients having non-cardiac surgery at three Melbourne teaching hospitals. Med J Aust 2007; 186: 447-452
132 Birkmeyer JD, Siewers AE, Finlayson EVA et al. Hospital volume and surgical mortality in the United States. NEJM 2002; 346: 1128-1137
133 Manfredi S, Piette C, Durand G et al. Colonoscopy results of a French regional FOBT-based colorectal cancer screening program with high compliance. Endoscopy 2008; 40: 422-427
134 Swan MP, Bourke MJ, Alexander S et al. Large refractory colonic polyps: is it time to change our practice? A prospective study of the clinical and economic impact of a tertiary referral colonic mucosal resection and polypectomy service. Gastrointest Endosc 2009; 70: 1128-1136
135 Moss A, Bourke MJ, Williams SJ et al. Endoscopic mucosal resection outcomes and prediction of submucosal cancer from advanced colonic mucosal neoplasia. Gastroenterol 2011; 140: 1909-1918
136 Dell’Abate P, Iosca A, Galimberti A et al. Endoscopic preoperative colonic tattooing; a colonic and surgical complication. Endoscopy 1999; 31: 271-273
137 Sawaki A, Nakamura T, Suzuki T et al. A two-step method for marking polypectomy sites in the colon and rectum. Gastrointest Endosc 2003; 57: 735-737
138 Enns R. Quality indicators in colonoscopy. Can J Gastroenterol 2007; 21: 277-279
139 Baxter NN, Sutradhar R, Forbes SS et al. Analysis of administrative data finds endoscopist quality measures associated with post-colonoscopy colorectal cancer. Gastroenterology 2011; 140: 65-72
140 Rex DK, Rahmani EY, Haseman JH et al. Relative sensitivity of colonoscopy and barium enema for detection of colorectal cancer in clinical practice. Gastroenterology 1997; 112: 17-23
141 Rabeneck L, Paszat LF, Hilsden RJ et al. Bleeding and perforation after outpatient colonoscopy and their risk factors in usual clinical practice. Gastroenterology 2008; 135: 1899-1906
142 Barton R. Validity and reliability of an accreditation assessment for colonoscopy. Gut 2008; 57 (Suppl. 01) A4
143 Gondal G, Grotmol T, Hofstad B et al. The Norwegian Colorectal Cancer Prevention [NORCCAP] screening study: baseline findings and implementations for clinical work-up in age groups 50–64 years. Scand J Gastroenterol 2003; 38: 635-642
144 Bowles CJ, Leicester R, Romaya C et al. A prospective study of colonoscopy practice in the UK today: are we adequately prepared for national colorectal cancer screening tomorrow?. Gut 2004; 53: 277-283
145 Gatto NM, Frucht H, Sundararajan V et al. Risk of perforation after colonoscopy and sigmoidoscopy: a population-based study. J Natl Cancer Inst 2006; 95: 230-236
146 Fruhmorgen P, Demling L. Complications of diagnostic and therapeutic colonoscopy in the Federal Republic of Germany. Results of an inquiry. Endoscopy 1979; 11: 146-150
147 Heldwein W, Dollhopf M, Rösch T et al. Munich Polypectomy Study (MUPS): prospective analysis of complications and risk factors in 4000 colonic snare polypectomies. Endoscopy 2005; 37: 1116-1122
148 Rosen L, Bub DS, Reed JF et al. Hemorrhage following colonoscopic polypectomy. Dis Colon Rectum 1993; 36: 1126-1131
149 Nelson DB, McQuaid KR, Bond JH et al. Procedural success and complications of large-scale screening colonoscopy. Gastrointest Endosc 2002; 55: 307-314
150 Friedland S, Sedehi D, Soetikno R. Colonoscopic polypectomy in anti-coagulated patients. World J Gastroenterol 2009; 15: 1973-1976
151 Hui AJ, Wong RM, Ching JY et al. Risk of colonoscopic polypectomy bleeding with anticoagulants and antiplatelet agents: analysis of 1657 cases. Gastrointest Endosc 2004; 59: 44-48
152 Rey JF, Beilenhoff U, Neumann CD et al. European Society of Gastrointestinal Endoscopy (ESGE) guideline: the use of electrosurgical units. Endoscopy 2010; 42: 764-771
153 Parra-Blanco A, Kaminaga N, Kojima T et al. Colonoscopic polypectomy with cutting current: is it safe?. Gastrointest Endosc 2000; 51: 676-681
154 Kim HS, Kim TI, Kim WH et al. Risk factors for immediate postpolyectomy bleeding of the colon: a multicenter study. Am J Gastroenterol 2006; 101: 1333-1341
155 Van Gossum A, Cozzoli A, Adler M et al. Colonoscopic snare polypectomy: analysis of 1485 resections comparing two types of current. Gastrointest Endosc 1992; 38: 472-475
156 Boustière C, Veitch A, Vanbiervliet G et al. Endoscopy and antiplatelet agents. European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy 2011; 43: 445-461
157 Rey JF, Lambert R. ESGE recommendations for quality control in gastrointestinal endoscopy: guidelines for image documentation in upper and lower GI. Endoscopy 2001; 33: 901-903
158 Beilenhoff U, Neumann CS, Rey JF et al. ESGE-ESGENA guideline: cleaning and disinfection in gastrointestinal endoscopy. Endoscopy 2008; 40: 939-957
159 Beilenhoff U, Neumann CS, Rey JF et al. ESGE–ESGENA guideline for quality assurance in reprocessing: microbiological surveillance testing in endoscopy. Endoscopy 2007; 39: 175-181
160 Rey JF, Kruse A. Cleaning and disinfection in Europe according to the endoscopic societies’ guidelines. Endoscopy 2003; 35: 878-881
161 International Organization for Standardization. DIN EN ISO 15883 Washer-disinfectors – Part 1: General requirements, terms and definitions and tests. 2006 http://www.iso.org
162 International Organization for Standardization. EN ISO 15883-4: 2008. Washer-disinfectors – Part 4: Requirements and tests for washer-disinfectors employing chemical disinfection for thermolabile endoscopes. http://www.iso.org
163 International Organization for Standardization. ISO/TS 15883-5; (2005) Washer-disinfectors – Part 5: Test soils and methods for demonstrating cleaning efficacy. 2005 http://www.iso.org