Influence of Perinatal Nutrition and Gestational Age on Neurodevelopment of Very Low-Birth-Weight Preterm Infants

Gabriela R. Filipouski; Rita C. Silveira; Renato S. Procianoy

doi:10.1055/s-0032-1331030

American Journal of Perinatology, Table of Contents

Am J Perinatol 2013; 30(08): 673-680
DOI: 10.1055/s-0032-1331030

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Influence of Perinatal Nutrition and Gestational Age on Neurodevelopment of Very Low-Birth-Weight Preterm Infants

Gabriela R. Filipouski

¹Department of Pediatrics, Newborn Section, Universidade Federal do Rio Grande do Sul and Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil

,

Rita C. Silveira

¹Department of Pediatrics, Newborn Section, Universidade Federal do Rio Grande do Sul and Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil

,

Renato S. Procianoy

¹Department of Pediatrics, Newborn Section, Universidade Federal do Rio Grande do Sul and Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil

› Author Affiliations

Abstract

Aim To assess the influence of gestational age and perinatal nutrition on development at 24 months' corrected age in a cohort of very low-birth-weight preterm infants.

Methods One hundred twenty-five very low-birth-weight preterm infants admitted to a neonatal intensive care unit within the first 48 hours of life were studied. The infants were classified as born small for gestational age (SGA) and still SGA at discharge (SGA/SGA); born adequate for gestational age (AGA) and SGA at discharge (AGA/SGA); and born AGA and still AGA age at discharge (AGA/AGA). The Bayley Scales of Infant and Toddler Development III (BSID-III) were used for assessment of neurodevelopment at 24 months' corrected age.

Results Fifty-six infants were classified as SGA/SGA, 55 as AGA/SGA, and 14 as AGA/AGA with no difference in BSID-III among the groups. By multiple linear regression analysis, the variables associated to better neurodevelopment outcome were higher gestational age and absence of grade III/IV periventricular/intraventricular hemorrhage.

Conclusion Immaturity is the most important variable associated with better neurodevelopment outcome in very preterm infants.

Keywords

adequate for gestational age - growth - neurodevelopment - preterm - small for gestational age

Full Text

References

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